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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/50707
Title: Oral Candida colonization in xerostomic postradiotherapy head and neck cancer patients
Authors: Supanat Tarapan
Oranart Matangkasombut
Dunyaporn Trachootham
Vanthana Sattabanasuk
Sineepat Talungchit
Wannaporn Paemuang
Tawaree Phonyiam
Orapin Chokchaitam
On ong Mungkung
Aroonwan Lam-ubol
Chulalongkorn University
Chulabhorn Research Institute
Mahidol University
Srinakharinwirot University
Chulabhorn Hospital
Chonburi Cancer Hospital
Keywords: Dentistry;Medicine
Issue Date: 1-Oct-2019
Citation: Oral Diseases. Vol.25, No.7 (2019), 1798-1808
Abstract: © 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. All rights reserved Objectives: To evaluate (a) oral colonization of Candida species, especially for non-albicans Candida species (NACS), in xerostomic postradiotherapy head and neck cancer patients and (b) risk factors affecting their colonization. Materials and methods: Subjective and objective dry mouth scores, stimulated salivary flow rates, pH and buffering capacity were measured in 72 xerostomic postradiotherapy head and neck cancer patients. Candida counts and species identification were performed using oral rinse samples cultured in Candida Chromagar, followed by polymerase chain reaction and API 20C AUX system. Results: Candida colonization was observed in 87.5% of subjects, with 80.6% and 48.6% of study population colonized by C. albicans and NACS, respectively. NACS was associated with high objective dry mouth scores, denture use, and females (p =.006,.009, and.036, respectively). In addition, Candida glabrata was detected more in females (p =.018) and denture wearers (p =.026), while Candida tropicalis was associated with high objective dry mouth scores (p =.022) and females (p =.027). Quantity of Candida colonization correlated positively with objective dry mouth scores (r = 0.599, p <.001) and negatively with salivary flow rates (r = −0.258, p =.041) and pH (r = −0.290, p =.022). Conclusion: NACS colonization was common in xerostomic head and neck cancer patients. Increased signs of dry mouth, female and dental prostheses may promote NACS colonization.
URI: http://repository.li.mahidol.ac.th/dspace/handle/123456789/50707
metadata.dc.identifier.url: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85070114086&origin=inward
ISSN: 16010825
1354523X
Appears in Collections:Scopus 2019

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