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Title: Urinary levels of phthalates and DINCH metabolites in Korean and Thai pregnant women across three trimesters
Authors: Gowoon Lee
Sungmin Kim
Younglim Kho
Sunmi Kim
Seonyeong Lee
Gyuyeon Choi
Jiwon Park
Suwalee Worakhunpiset
Hyo Bang Moon
Kamolnetr Okanurak
Malee Geounuppakul
Jirat Tangtitawong
Kasem Wetsutthanon
Daungprateep Trisurat
Kyungho Choi
Eulji University
Hanyang University
Soonchunhyang University, College of Medicine
Seoul National University
Mahidol University
Metropolitan and Wellness Institute of Health
Cheongdam Yeon & Nature Obestetrics & Gynecology
CentralBio Co., Ltd.
Maternal and Child Health consultant
Korea Environmental Industry & Technology Institute
Boromarajonani College of Nursing
Keywords: Environmental Science
Issue Date: 1-Jan-2019
Citation: Science of the Total Environment. (2019)
Abstract: © 2019 Elsevier B.V. Phthalates are anti-androgenic chemicals and may cause long-lasting adverse effects on growing fetuses. Understanding their exposure profile during pregnancy, therefore, is of public health importance. Because both behavioral and physiological changes of pregnant women are expected to be substantial, the amount of phthalate exposure is expected to vary significantly over the course of pregnancy. Temporal trend of phthalate exposure during pregnancy, however, is largely unknown, especially in Asian women. The purpose of this study is to investigate the urinary concentrations of metabolites for major phthalates and alternative plasticizers over the course of pregnancy among Korean (n = 81) and Thai women (n = 102). Twenty-four metabolites from 15 plasticizers, such as dimethyl phthalate (DMP), diethyl phthalate (DEP), di-isobutyl phthalate (DiBP), di-n-butyl phthalate (DnBP), benzyl butyl phthalate (BBzP), di(2-ethylhexyl) phthalate (DEHP), dioctyl phthalate (DnOP), diisononyl phthalate (DiNP), diisodecyl phthalate (DiDP), di(2-ethylhexyl) terephthalate (DEHTP), and di-(iso-nonyl)-cyclohexane-1,2-dicarboxylate (DINCH), were measured in urine samples collected in each trimester from pregnant women. While the levels of several phthalate metabolites were significantly different by trimester among Korean women, those of Thai women were relatively consistent. Urinary metabolites of DEP and DnOP were higher in Thai pregnant women compared to Korean pregnant women. The detection frequencies of the DINCH metabolite were 67.4% and 44.9% among Korean and Thai pregnant women, respectively. However, the ratio of DINCH to DEHP metabolites was significantly higher in Thai women. According to risk assessment, 11.9% of Korean and 5.3% of Thai women were considered at risk due to phthalate exposure, and DEHP, DnBP and DiBP were identified as major risk drivers. Considering the vulnerability of growing fetuses, further studies are warranted to identify major sources of exposure to these plasticizers during pregnancy.
ISSN: 18791026
Appears in Collections:Scopus 2019

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