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Title: Is running associated with a lower risk of all-cause, cardiovascular and cancer mortality, and is the more the better? A systematic review and meta-analysis
Authors: Zeljko Pedisic
Nipun Shrestha
Stephanie Kovalchik
Emmanuel Stamatakis
Nucharapon Liangruenrom
Jozo Grgic
Sylvia Titze
Stuart J.H. Biddle
Adrian E. Bauman
Pekka Oja
Victoria University Melbourne, Institute for Health and Sport
The University of Sydney
Karl-Franzens-Universitat Graz
University of Southern Queensland
UKK Institute Finland
Mahidol University
Keywords: Health Professions
Issue Date: 1-Jan-2019
Citation: British Journal of Sports Medicine. (2019)
Abstract: © Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ. Objective: To investigate the association of running participation and the dose of running with the risk of all-cause, cardiovascular and cancer mortality. Design: Systematic review and meta-analysis. Data sources: Journal articles, conference papers and doctoral theses indexed in Academic Search Ultimate, CINAHL, Health Source: Nursing/Academic Edition, MasterFILE Complete, Networked Digital Library of Theses and Dissertations, Open Access Theses and Dissertations, PsycINFO, PubMed/MEDLINE, Scopus, SPORTDiscus and Web of Science. Eligibility criteria for selecting studies: Prospective cohort studies on the association between running or jogging participation and the risk of all-cause, cardiovascular and/or cancer mortality in a non-clinical population of adults were included. Results: Fourteen studies from six prospective cohorts with a pooled sample of 232 149 participants were included. In total, 25 951 deaths were recorded during 5.5-35 year follow-ups. Our meta-analysis showed that running participation is associated with 27%, 30% and 23% lower risk of all-cause (pooled adjusted hazard ratio (HR)=0.73; 95% confidence interval (CI) 0.68 to 0.79), cardiovascular (HR=0.70; 95% CI 0.49 to 0.98) and cancer (HR=0.77; 95% CI 0.68 to 0.87) mortality, respectively, compared with no running. A meta-regression analysis showed no significant dose-response trends for weekly frequency, weekly duration, pace and the total volume of running. Conclusion: Increased rates of participation in running, regardless of its dose, would probably lead to substantial improvements in population health and longevity. Any amount of running, even just once a week, is better than no running, but higher doses of running may not necessarily be associated with greater mortality benefits.
ISSN: 14730480
Appears in Collections:Scopus 2019

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