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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/51015
Title: A protective Zika virus E-dimer-based subunit vaccine engineered to abrogate antibody-dependent enhancement of dengue infection
Authors: Jose Luis Slon-Campos
Wanwisa Dejnirattisai
Brett W. Jagger
César López-Camacho
Wiyada Wongwiwat
Lorellin A. Durnell
Emma S. Winkler
Rita E. Chen
Arturo Reyes-Sandoval
Felix A. Rey
Michael S. Diamond
Juthathip Mongkolsapaya
Gavin R. Screaton
Western Michigan University Homer Stryker M.D. School of Medicine
University of Oxford
Washington University School of Medicine in St. Louis
Faculty of Medicine, Siriraj Hospital, Mahidol University
Nuffield Department of Clinical Medicine
CNRS Centre National de la Recherche Scientifique
Institut Pasteur, Paris
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Oct-2019
Citation: Nature Immunology. Vol.20, No.10 (2019), 1291-1298
Abstract: © 2019, The Author(s), under exclusive licence to Springer Nature America, Inc. Infections with dengue virus (DENV) and Zika virus (ZIKV) can induce cross-reactive antibody responses. Two immunodominant epitopes—one to precursor membrane protein and one to the fusion loop epitope on envelope (E) protein—are recognized by cross-reactive antibodies1–3 that are not only poorly neutralizing, but can also promote increased viral replication and disease severity via Fcγ receptor-mediated infection of myeloid cells—a process termed antibody-dependent enhancement (ADE)1,4,5. ADE is a significant concern for both ZIKV and DENV vaccines as the induction of poorly neutralizing cross-reactive antibodies may prime an individual for ADE on natural infection. In this report, we describe the design and production of covalently stabilized ZIKV E dimers, which lack precursor membrane protein and do not expose the immunodominant fusion loop epitope. Immunization of mice with ZIKV E dimers induces dimer-specific antibodies, which protect against ZIKV challenge during pregnancy. Importantly, the ZIKV E-dimer-induced response does not cross-react with DENV or induce ADE of DENV infection.
URI: http://repository.li.mahidol.ac.th/dspace/handle/123456789/51015
metadata.dc.identifier.url: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85071686228&origin=inward
ISSN: 15292916
15292908
Appears in Collections:Scopus 2019

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