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Title: The role of galectins in virus infection - A systemic literature review
Authors: Wen Hung Wang
Chih Yen Lin
Max R. Chang
Aspiro Nayim Urbina
Wanchai Assavalapsakul
Arunee Thitithanyanont
Yen Hsu Chen
Fu Tong Liu
Sheng Fan Wang
Kaohsiung Medical University Chung-Ho Memorial Hospital
Chulalongkorn University
Academia Sinica, Institute of Biomedical Sciences
Mahidol University
National Chiao Tung University Taiwan
Kaohsiung Medical University
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Jan-2019
Citation: Journal of Microbiology, Immunology and Infection. (2019)
Abstract: © 2019 Background: Galectins are β-Galactose binding lectins expressed in numerous cells and play multiple roles in various physiological and cellular functions. However, few information is available regarding the role of galectins in virus infections. Here, we conducted a systemic literature review to analyze the role of galectins in human virus infection. Methods: This study uses a systematic method to identify and select eligible articles according to the PRISMA guidelines. References were selected from PubMed, Web of Science and Google Scholar database covering publication dated from August 1995 to December 2018. Results: Results indicate that galectins play multiple roles in regulation of virus infections. Galectin-1 (Gal-1), galectin-3 (Gal-3), galectin-8 (Gal-8), and galectin-9 (Gal-9) were found as the most predominant galectins reported to participate in virus infection. The regulatory function of galectins occurs by extracellularly binding to viral glycosylated envelope proteins, interacting with ligands or receptors on immune cells, or acting intracellularly with viral or cellular components in the cytoplasm. Several galectins express either positive or negative regulatory role, while some had dual regulatory capabilities on virus propagation based on the conditions and their localization. However, limited information about the endogenous function of galectins were found. Therefore, the endogenous effects of galectins in host-virus regulation remains valuable to investigate. Conclusions: This study offers information regarding the various roles galectins shown in viral infection and suggest that galectins can potentially be used as viral therapeutic targets or antagonists.
ISSN: 19959133
Appears in Collections:Scopus 2019

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