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dc.contributor.authorWen Hung Wangen_US
dc.contributor.authorChih Yen Linen_US
dc.contributor.authorMax R. Changen_US
dc.contributor.authorAspiro Nayim Urbinaen_US
dc.contributor.authorWanchai Assavalapsakulen_US
dc.contributor.authorArunee Thitithanyanonten_US
dc.contributor.authorYen Hsu Chenen_US
dc.contributor.authorFu Tong Liuen_US
dc.contributor.authorSheng Fan Wangen_US
dc.contributor.otherKaohsiung Medical University Chung-Ho Memorial Hospitalen_US
dc.contributor.otherChulalongkorn Universityen_US
dc.contributor.otherAcademia Sinica, Institute of Biomedical Sciencesen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherNational Chiao Tung University Taiwanen_US
dc.contributor.otherKaohsiung Medical Universityen_US
dc.identifier.citationJournal of Microbiology, Immunology and Infection. (2019)en_US
dc.description.abstract© 2019 Background: Galectins are β-Galactose binding lectins expressed in numerous cells and play multiple roles in various physiological and cellular functions. However, few information is available regarding the role of galectins in virus infections. Here, we conducted a systemic literature review to analyze the role of galectins in human virus infection. Methods: This study uses a systematic method to identify and select eligible articles according to the PRISMA guidelines. References were selected from PubMed, Web of Science and Google Scholar database covering publication dated from August 1995 to December 2018. Results: Results indicate that galectins play multiple roles in regulation of virus infections. Galectin-1 (Gal-1), galectin-3 (Gal-3), galectin-8 (Gal-8), and galectin-9 (Gal-9) were found as the most predominant galectins reported to participate in virus infection. The regulatory function of galectins occurs by extracellularly binding to viral glycosylated envelope proteins, interacting with ligands or receptors on immune cells, or acting intracellularly with viral or cellular components in the cytoplasm. Several galectins express either positive or negative regulatory role, while some had dual regulatory capabilities on virus propagation based on the conditions and their localization. However, limited information about the endogenous function of galectins were found. Therefore, the endogenous effects of galectins in host-virus regulation remains valuable to investigate. Conclusions: This study offers information regarding the various roles galectins shown in viral infection and suggest that galectins can potentially be used as viral therapeutic targets or antagonists.en_US
dc.rightsMahidol Universityen_US
dc.subjectImmunology and Microbiologyen_US
dc.titleThe role of galectins in virus infection - A systemic literature reviewen_US
Appears in Collections:Scopus 2019

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