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Title: Incidence of atrial fibrillation in pregnancy and clinical significance: A meta-analysis
Authors: Ronpichai Chokesuwattanaskul
Charat Thongprayoon
Tarun Bathini
Oisin A. O'Corragain
Konika Sharma
Somchai Prechawat
Patompong Ungprasert
Kanramon Watthanasuntorn
Pavida Pachariyanon
Wisit Cheungpasitporn
Texas Tech University Health Sciences Center at Lubbock
Temple University
Faculty of Medicine, Siriraj Hospital, Mahidol University
University of Arizona
Mayo Clinic
University of Mississippi Medical Center
Faculty of Medicine, Chulalongkorn University
Bassett Medical Center
Keywords: Medicine
Issue Date: 1-Sep-2019
Citation: Advances in Medical Sciences. Vol.64, No.2 (2019), 415-422
Abstract: © 2019 Medical University of Bialystok Purpose: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia worldwide, and is associated with increased morbidity and mortality. However, the incidence and maternal/fetal outcomes of AF in pregnancy remain unclear. This study's aims were to investigate the pooled incidence of AF in pregnant women and to assess maternal/fetal outcomes of AF in pregnancy. Material and methods: A literature search for studies that reported incidence of AF in pregnancy, was conducted using MEDLINE, EMBASE and Cochrane Database from inception through May 2018. Pooled incidence with 95%CI were calculated using a random-effect model. The protocol for this meta-analysis is registered with PROSPERO (International Prospective Register of Systematic Reviews; no. CRD42018095955). Results: We identified 7 cohort studies including 301,638 pregnancies. The pooled estimated incidence of AF in pregnancy among women with no known heart disease, and those with structural heart disease was 0.3% (95%CI: 0.01%–40.6%) and 2.2% (95%CI: 0.96%–5.01%), respectively. Among women with known AF, the pooled estimated incidence of recurrent AF in pregnancy was 39.2% (95%CI: 16.9%–67.2%). The pooled estimated incidence of pre-eclampsia and congestive heart failure among pregnant patients with AF was 4.1% (95%CI: 2.1%–7.8%) and 9.6% (95%CI: 5.7%–15.9%), respectively. The pooled estimated incidence of fetal events including premature birth, small for gestational age, respiratory distress syndrome, intraventricular hemorrhage, death was 26.6% (95%CI: 20.4%–34.0%). Conclusion: The overall estimated incidence of AF and recurrent AF during pregnancy is as high as 2.2% and 39.2%, respectively. AF during pregnancy may result in poor maternal and fetal outcomes.
ISSN: 18984002
Appears in Collections:Scopus 2019

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