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Title: Factors associated with low health-related quality of life among younger and older Thai patients with non-valvular atrial fibrillation
Authors: Varalak Srinonprasert
Kasem Ratanasumawong
Tomon Thongsri
Somchai Dutsadeevettakul
Pongpun Jittham
Weerapan Wiwatworapan
Rungroj Krittayaphong
Tomorn Thongsri
Kriengkrai Hengrussamee
Pattraporn Srirattana
Wattana Wongtheptien
Pornchai Ngamjanyaporn
Arintaya Phrommintikul
Smonporn Boonyaratavej
Treechada Wisaratapong
Sirin Apiyasawat
Arjbordin Winijkul
Rungroj Krittayaphong
Roj Rojjarekampai
Kulyot Jongpiputvanich
Chaiyasith Wongvipaporn
Thanita Boonyapiphat
Khanchai Siriwattana
Eakarnantha Arnanththanitha
Watchara Konkaew
Thoranis Chantrarat
Wiwat Kanjanarutjawiwat
Sakaorat Kornbongkotmas
Thanasak Patmuk
Praprut Thanakitcharu
Suchart Arunsiriwattana
Thaworn Choochunklin
Sumon Tangsuntornwiwat
Police General Hospital
Naresuan University
Buddhachinaraj Hospital
Faculty of Medicine, Siriraj Hospital, Mahidol University
Golden Jubilee Medical Center
Maharat Nakornratchasima Hospital
Keywords: Medicine
Issue Date: 15-Aug-2019
Citation: Quality of Life Research. Vol.28, No.8 (2019), 2091-2098
Abstract: © 2019, Springer Nature Switzerland AG. Purpose: The aim of this study was to investigate the factors associated with low health-related quality of life (HRQoL) compared between younger and older Thai patients with non-valvular atrial fibrillation (NVAF). Methods: This is a cross-sectional analysis of baseline data from a prospective NVAF registry from 24 hospitals located across Thailand. Patient demographic, clinical, lifestyle, and medication data were collected at baseline. EuroQOL/EQ-5D-3L was used to assess HRQoL. Health utility was calculated for the entire study population, and low HRQoL was defined as the lowest quartile. Multivariate logistic regression was used to identify factors that significantly predict low HRQoL among younger and older (≥ 65 years) patients with NVAF. Results: Among the 3218 participants that were enrolled, 61.0% were aged older than 65 years. Mean HRQoL was lower in older than in younger patients (0.72 ± 0.26 vs. 0.84 ± 0.20; p < 0.001). Factors associated with low HRQoL among younger NVAF patients were the treatment-related factors bleeding history (p = 0.006) and taking warfarin (p = 0.001). Among older patients, the NVAF-related complications ischemic stroke or TIA, heart failure (HF), and dementia (all p < 0.001) were all significantly associated with low HRQoL. Dementia is the factor that most adversely influences low HRQoL among older NVAF. Interestingly, symptomatic NVAF was found to be a protective factor for low HRQoL (p < 0.001). Conclusions: Bleeding history and taking warfarin among younger patients, and ischemic stroke/TIA, HF, and dementia among older patients are significant predictors of low HRQoL. These factors should be taken into consideration when selecting treatment options for patients with NVAF.
ISSN: 15732649
Appears in Collections:Scopus 2019

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