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Title: Long-term loss to follow-up in the TREAT Asia HIV Observational Database (TAHOD)
Authors: A. Jiamsakul
S. Kiertiburanakul
O. T. Ng
R. Chaiwarith
W. Wong
R. Ditangco
K. V. Nguyen
A. Avihingsanon
S. Pujari
C. D. Do
M. P. Lee
P. S. Ly
E. Yunihastuti
N. Kumarasamy
A. Kamarulzaman
J. Tanuma
F. Zhang
J. Y. Choi
P. Kantipong
B. L.H. Sim
J. Ross
M. Law
T. P. Merati
P. S. Ly
V. Khol
F. J. Zhang
H. X. Zhao
N. Han
M. P. Lee
P. C.K. Li
W. Lam
Y. T. Chan
N. Kumarasamy
S. Saghayam
C. Ezhilarasi
S. Pujari
K. Joshi
S. Gaikwad
A. Chitalikar
S. Sangle
V. Mave
I. Marbaniang
T. P. Merati
D. N. Wirawan
F. Yuliana
E. Yunihastuti
D. Imran
A. Widhani
J. Tanuma
S. Oka
T. Nishijima
J. Y. Choi
S. Na
J. M. Kim
B. L.H. Sim
Y. M. Gani
N. B. Rudi
A. Kamarulzaman
S. F. Syed Omar
S. Ponnampalavanar
I. Azwa
R. Ditangco
M. K. Pasayan
M. L. Mationg
W. W. Wong
W. W. Ku
P. C. Wu
O. T. Ng
P. L. Lim
L. S. Lee
Z. Ferdous
A. vihingsanon
S. Gatechompol
P. Phanuphak
C. Phadungphon
S. Kiertiburanakul
A. Phuphuakrat
L. Chumla
N. Sanmeema
R. Chaiwarith
T. Sirisanthana
W. Kotarathititum
J. Praparattanapan
S. Khusuwan
K. V. Nguyen
H. V. Bui
D. T.H. Nguyen
D. T. Nguyen
C. D. Do
A. V. Ngo
L. T. Nguyen
A. H. Sohn
L. Ross
B. Petersen
M. G. Law
D. Rupasinghe
The Voluntary Health Services, Chennai
Hospital Sungai Buloh
Beijing Ditan Hospital Capital Medical University
Bach Mai Hospital
Universitas Udayana
University of Indonesia, RSUPN Dr. Cipto Mangunkusumo
Chulalongkorn University
Kirby Institute
National Center for Global Health and Medicine
Yonsei University College of Medicine
Faculty of Medicine, Ramathibodi Hospital, Mahidol University
Queen Elizabeth Hospital Hong Kong
University of Malaya Medical Centre
Veterans General Hospital-Taipei
Tan Tock Seng Hospital
Chiang Mai University
University of Health Sciences
National Hospital for Tropical Diseases
Foundation for AIDS Research
Institute of Infectious Diseases
Chiangrai Prachanukroh Hospital
Keywords: Medicine
Issue Date: 1-Aug-2019
Citation: HIV Medicine. Vol.20, No.7 (2019), 439-449
Abstract: © 2019 British HIV Association Objectives: With earlier antiretroviral therapy (ART) initiation, time spent in HIV care is expected to increase. We aimed to investigate loss to follow-up (LTFU) in Asian patients who remained in care 5 years after ART initiation. Methods: Long-term LTFU was defined as LTFU occurring after 5 years on ART. LTFU was defined as (1) patients not seen in the previous 12 months; and (2) patients not seen in the previous 6 months. Factors associated with LTFU were analysed using competing risk regression. Results: Under the 12-month definition, the LTFU rate was 2.0 per 100 person-years (PY) [95% confidence interval (CI) 1.8–2.2 among 4889 patients included in the study. LTFU was associated with age > 50 years [sub-hazard ratio (SHR) 1.64; 95% CI 1.17–2.31] compared with 31–40 years, viral load ≥ 1000 copies/mL (SHR 1.86; 95% CI 1.16–2.97) compared with viral load < 1000 copies/mL, and hepatitis C coinfection (SHR 1.48; 95% CI 1.06–2.05). LTFU was less likely to occur in females, in individuals with higher CD4 counts, in those with self-reported adherence ≥ 95%, and in those living in high-income countries. The 6-month LTFU definition produced an incidence rate of 3.2 per 100 PY (95% CI 2.9–3.4 and had similar associations but with greater risks of LTFU for ART initiation in later years (2006–2009: SHR 2.38; 95% CI 1.93–2.94; and 2010–2011: SHR 4.26; 95% CI 3.17–5.73) compared with 2003–2005. Conclusions: The long-term LTFU rate in our cohort was low, with older age being associated with LTFU. The increased risk of LTFU with later years of ART initiation in the 6-month analysis, but not the 12-month analysis, implies that there was a possible move towards longer HIV clinic scheduling in Asia.
ISSN: 14681293
Appears in Collections:Scopus 2019

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