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Title: Heart failure with reduced ejection fraction: comparison of patient characteristics and clinical outcomes within Asia and between Asia, Europe and the Americas
Authors: Pooja Dewan
Pardeep S. Jhund
Li Shen
Mark C. Petrie
William T. Abraham
M. Atif Ali
Chen Huan Chen
Akshay S. Desai
Kenneth Dickstein
Jun Huang
Songsak Kiatchoosakun
Kee Sik Kim
Lars Køber
Wen Ter Lai
Yuhua Liao
Ulrik M. Mogensen
Byung Hee Oh
Milton Packer
Jean L. Rouleau
Victor Shi
Antonio S. Sibulo
Scott D. Solomon
Piyamitr Sritara
Karl Swedberg
Hiroyuki Tsutsui
Michael R. Zile
John J.V. McMurray
Jiangsu Province Hospital
Baylor Jack and Jane Hamilton Heart and Vascular Hospital
Kaohsiung Medical University Chung-Ho Memorial Hospital
Universitetet i Bergen
Medical University of South Carolina
Seoul National University Hospital
Khon Kaen University
Brigham and Women's Hospital
Göteborgs Universitet
Faculty of Medicine, Ramathibodi Hospital, Mahidol University
Institut de Cardiologie de Montreal
National Heart and Lung Institute
Kyushu University, Faculty of Medical Sciences
National Yang-Ming University, School of Medicine
Ohio State University
University of Glasgow
Tongji Medical College
Novartis Pharmaceuticals Corporation
St. Luke's Medical Centre
Daegu Catholic University Medical Centre
Keywords: Medicine
Issue Date: 1-May-2019
Citation: European Journal of Heart Failure. Vol.21, No.5 (2019), 577-587
Abstract: © 2018 The Authors. European Journal of Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology. Aims: Nearly 60% of the world's population lives in Asia but little is known about the characteristics and outcomes of Asian patients with heart failure with reduced ejection fraction (HFrEF) compared to other areas of the world. Methods and results: We pooled two, large, global trials, with similar design, in 13 174 patients with HFrEF (patient distribution: China 833, India 1390, Japan 209, Korea 223, Philippines 223, Taiwan 199 and Thailand 95, Western Europe 3521, Eastern Europe 4758, North America 613, and Latin America 1110). Asian patients were younger (55.0–63.9 years) than in Western Europe (67.9 years) and North America (66.6 years). Diuretics and devices were used less, and digoxin used more, in Asia. Mineralocorticoid receptor antagonist use was higher in China (66.3%), the Philippines (64.1%) and Latin America (62.8%) compared to Europe and North America (range 32.8% to 49.6%). The rate of cardiovascular death/heart failure hospitalization was higher in Asia (e.g. Taiwan 17.2, China 14.9 per 100 patient-years) than in Western Europe (10.4) and North America (12.8). However, the adjusted risk of cardiovascular death was higher in many Asian countries than in Western Europe (except Japan) and the risk of heart failure hospitalization was lower in India and in the Philippines than in Western Europe, but significantly higher in China, Japan, and Taiwan. Conclusion: Patient characteristics and outcomes vary between Asia and other regions and between Asian countries. These variations may reflect several factors, including geography, climate and environment, diet and lifestyle, health care systems, genetics and socioeconomic influences.
ISSN: 18790844
Appears in Collections:Scopus 2019

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