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dc.contributor.authorPooja Dewanen_US
dc.contributor.authorPardeep S. Jhunden_US
dc.contributor.authorLi Shenen_US
dc.contributor.authorMark C. Petrieen_US
dc.contributor.authorWilliam T. Abrahamen_US
dc.contributor.authorM. Atif Alien_US
dc.contributor.authorChen Huan Chenen_US
dc.contributor.authorAkshay S. Desaien_US
dc.contributor.authorKenneth Dicksteinen_US
dc.contributor.authorJun Huangen_US
dc.contributor.authorSongsak Kiatchoosakunen_US
dc.contributor.authorKee Sik Kimen_US
dc.contributor.authorLars Køberen_US
dc.contributor.authorWen Ter Laien_US
dc.contributor.authorYuhua Liaoen_US
dc.contributor.authorUlrik M. Mogensenen_US
dc.contributor.authorByung Hee Ohen_US
dc.contributor.authorMilton Packeren_US
dc.contributor.authorJean L. Rouleauen_US
dc.contributor.authorVictor Shien_US
dc.contributor.authorAntonio S. Sibuloen_US
dc.contributor.authorScott D. Solomonen_US
dc.contributor.authorPiyamitr Sritaraen_US
dc.contributor.authorKarl Swedbergen_US
dc.contributor.authorHiroyuki Tsutsuien_US
dc.contributor.authorMichael R. Zileen_US
dc.contributor.authorJohn J.V. McMurrayen_US
dc.contributor.otherJiangsu Province Hospitalen_US
dc.contributor.otherBaylor Jack and Jane Hamilton Heart and Vascular Hospitalen_US
dc.contributor.otherKaohsiung Medical University Chung-Ho Memorial Hospitalen_US
dc.contributor.otherUniversitetet i Bergenen_US
dc.contributor.otherMedical University of South Carolinaen_US
dc.contributor.otherSeoul National University Hospitalen_US
dc.contributor.otherKhon Kaen Universityen_US
dc.contributor.otherBrigham and Women's Hospitalen_US
dc.contributor.otherGöteborgs Universiteten_US
dc.contributor.otherFaculty of Medicine, Ramathibodi Hospital, Mahidol Universityen_US
dc.contributor.otherInstitut de Cardiologie de Montrealen_US
dc.contributor.otherNational Heart and Lung Instituteen_US
dc.contributor.otherKyushu University, Faculty of Medical Sciencesen_US
dc.contributor.otherNational Yang-Ming University, School of Medicineen_US
dc.contributor.otherOhio State Universityen_US
dc.contributor.otherUniversity of Glasgowen_US
dc.contributor.otherTongji Medical Collegeen_US
dc.contributor.otherNovartis Pharmaceuticals Corporationen_US
dc.contributor.otherSt. Luke's Medical Centreen_US
dc.contributor.otherDaegu Catholic University Medical Centreen_US
dc.identifier.citationEuropean Journal of Heart Failure. Vol.21, No.5 (2019), 577-587en_US
dc.description.abstract© 2018 The Authors. European Journal of Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology. Aims: Nearly 60% of the world's population lives in Asia but little is known about the characteristics and outcomes of Asian patients with heart failure with reduced ejection fraction (HFrEF) compared to other areas of the world. Methods and results: We pooled two, large, global trials, with similar design, in 13 174 patients with HFrEF (patient distribution: China 833, India 1390, Japan 209, Korea 223, Philippines 223, Taiwan 199 and Thailand 95, Western Europe 3521, Eastern Europe 4758, North America 613, and Latin America 1110). Asian patients were younger (55.0–63.9 years) than in Western Europe (67.9 years) and North America (66.6 years). Diuretics and devices were used less, and digoxin used more, in Asia. Mineralocorticoid receptor antagonist use was higher in China (66.3%), the Philippines (64.1%) and Latin America (62.8%) compared to Europe and North America (range 32.8% to 49.6%). The rate of cardiovascular death/heart failure hospitalization was higher in Asia (e.g. Taiwan 17.2, China 14.9 per 100 patient-years) than in Western Europe (10.4) and North America (12.8). However, the adjusted risk of cardiovascular death was higher in many Asian countries than in Western Europe (except Japan) and the risk of heart failure hospitalization was lower in India and in the Philippines than in Western Europe, but significantly higher in China, Japan, and Taiwan. Conclusion: Patient characteristics and outcomes vary between Asia and other regions and between Asian countries. These variations may reflect several factors, including geography, climate and environment, diet and lifestyle, health care systems, genetics and socioeconomic influences.en_US
dc.rightsMahidol Universityen_US
dc.titleHeart failure with reduced ejection fraction: comparison of patient characteristics and clinical outcomes within Asia and between Asia, Europe and the Americasen_US
Appears in Collections:Scopus 2019

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