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Title: Abnormal red blood cell indices increase the risk of arterial ischemic stroke in children
Authors: Chaiyos Khongkhatithum
Praguywan Kadegasem
Werasak Sasanakul
Lunliya Thampratankul
Ampaiwan Chuansumrit
Nongnuch Sirachainan
Faculty of Medicine, Ramathibodi Hospital, Mahidol University
Keywords: Medicine
Issue Date: 1-Apr-2019
Citation: Journal of Clinical Neuroscience. Vol.62, (2019), 117-120
Abstract: © 2018 Elsevier Ltd A high red cell distribution width (RDW) and low hemoglobin level increase the risk of arterial ischemic stroke (AIS), mostly in adults. The mechanisms related to AIS remain unknown. A total of 233 subjects (90 patients and 143 healthy controls [HC]) were enrolled. The mean(SD) age in patients and HC was 9.5(3.8) and 11.4(1.8) years, respectively. We found increased odds ratios (ORs) for large vessel and small vessel subtypes in patients without underlying diseases with a mean corpuscular volume (MCV) <80 fL (OR: 5.4, 95%CI 1.8–16.3 and 2.8, 95%CI 1.2–7.2), mean corpuscular hemoglobin levels <27 pg (OR: 2.9, 95%CI 1.0–6.7 and 2.6, 95%CI 1.0–6.7), and RDW >15% (OR: 5.5, 95%CI 1.3–24.5 and 2.7, 95%CI 1.0–7.3). RBC indices showed significant correlations with TM levels. Therefore, low MCV and MCH levels, and a high RDW were risk factors for AIS and associated with TM levels in this population.
ISSN: 15322653
Appears in Collections:Scopus 2019

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