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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/51778
Title: Epidemiology of atrial fibrillation in patients with cirrhosis and clinical significance: A meta-analysis
Authors: Ronpichai Chokesuwattanaskul
Charat Thongprayoon
Tarun Bathini
Oisin A. O'Corragain
Konika Sharma
Somchai Preechawat
Karn Wijarnpreecha
Paul T. Kröner
Patompong Ungprasert
Wisit Cheungpasitporn
Chulalongkorn University
Temple University Hospital
Faculty of Medicine, Siriraj Hospital, Mahidol University
University of Arizona
Mayo Clinic
University of Mississippi Medical Center
Mayo Clinic in Jacksonville, Florida
Bassett Medical Center
Keywords: Medicine
Issue Date: 1-Apr-2019
Citation: European Journal of Gastroenterology and Hepatology. Vol.31, No.4 (2019), 514-519
Abstract: Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved. Objective The epidemiology of atrial fibrillation (AF) in patients with cirrhosis and its clinical significance remain unclear. This study aimed (i) to investigate the pooled prevalence and/or incidence of AF in patients with cirrhosis and (ii) to assess the mortality risk of AF in patients with cirrhosis. Patients and methods A literature search for studies that reported incidence of AF in patients with cirrhosis was carried out using Medline, Embase, and Cochrane Database from inception through July 2018. Pooled incidence with 95% confidence interval (CI) was calculated using a random-effect model. The protocol for this meta-analysis is registered with PROSPERO (International Prospective Register of Systematic Reviews; no. CRD42018102664). Results Seven cohort studies including 385 866 patients with cirrhosis were identified. The pooled estimated prevalence of AF in patients with cirrhosis was 5.0% (95% CI: 2.8-8.6%). When studies that solely assessed patients undergoing transplant evaluation or on transplant waiting list were excluded, the pooled estimated prevalence of AF in patients with cirrhosis was 7.4% (95% CI: 3.5-15.2%). There was a significant association between AF and increased mortality risk in cirrhotic patients with a pooled odds ratio of 1.44 (95% CI: 1.36-1.53). Conclusion The overall estimated prevalence of AF among patients with cirrhosis is 5.0%. Our study demonstrates a statistically significant increased mortality risk in cirrhotic patients with AF.
URI: http://repository.li.mahidol.ac.th/dspace/handle/123456789/51778
metadata.dc.identifier.url: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85062401151&origin=inward
ISSN: 14735687
0954691X
Appears in Collections:Scopus 2019

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