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Title: Clozapine-induced agranulocytosis and leukopenia: Incidence, associated factors, and rate of hematologic adverse-effects monitoring in psychiatric out-patient services in Thailand
Authors: Noppawan Tunsirimas
Pornjira Pariwatcharakul
Somrak Choovanichvong
Woraphat Ratta-apha
Srithanya Hospital
Faculty of Medicine, Siriraj Hospital, Mahidol University
Nakorn Ratchasima Rajanagarindra Psychiatric Hospital
Keywords: Medicine
Issue Date: 1-Mar-2019
Citation: Asian Journal of Psychiatry. Vol.41, (2019), 13-16
Abstract: © 2019 Elsevier B.V. The present study aimed to investigate the incidence of agranulocytosis and leukopenia and its associated factors in Thai schizophrenia patients treated with clozapine and the rate of hematologic adverse events monitored in clinical practice. Data were collected from the medical records of 641 outpatients at two hospitals. The results showed no cases of agranulocytosis and 20 cases of leukopenia (3.1%), 85% of which were observed after 1 year of prescription. The associated factors were female (p = 0.019) and duration of clozapine prescription (p = 0.026). According to the guideline for safety monitoring, 23.6% of cases had neutrophils count monitoring.
ISSN: 18762026
Appears in Collections:Scopus 2019

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