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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/51845
Title: Impact of diabetes and sex in heart failure with reduced ejection fraction patients from the ASIAN-HF registry
Authors: Chanchal Chandramouli
Tiew Hwa Katherine Teng
Wan Ting Tay
Jonathan Yap
Michael R. MacDonald
Jasper Tromp
Limin Yan
Bambang Siswanto
Eugenio B. Reyes
Tachapong Ngarmukos
Cheuk Man Yu
Chung Lieh Hung
Inder Anand
A. Mark Richards
Lieng Hsi Ling
Judith G. Regensteiner
Carolyn S.P. Lam
A. Mark Richards
Carolyn S.P. Lam
Inder Anand
Chung Lieh Hung
Lieng Hsi Ling
Houng Bang Liew
Calambur Narasimhan
Sang Weon Park
Eugenio Reyes
Bambang B. Siswanto
Wataru Shimizu
Shu Zhang
Manila Doctors Hospital
Care Hospital Hyderabad
Universitas Indonesia
Mackay Memorial Hospital Taiwan
University of Colorado School of Medicine
Nippon Medical School
University of Otago
National University of Singapore
Faculty of Medicine, Ramathibodi Hospital, Mahidol University
VA Medical Center
Changi General Hospital
University of Minnesota Medical School
University of Groningen, University Medical Center Groningen
National Heart Centre, Singapore
Chinese University of Hong Kong
Queen Elizabeth Hospital
Cardiovascular Research Institute
Fuwai Cardiovascular Hospital
Sejong General Hospital
Keywords: Medicine
Issue Date: 1-Mar-2019
Citation: European Journal of Heart Failure. Vol.21, No.3 (2019), 297-307
Abstract: © 2018 The Authors. European Journal of Heart Failure © 2018 European Society of Cardiology Aims: To examine sex differences in clinical characteristics, echocardiographic features, quality of life and 1-year death or heart failure (HF) hospitalization outcomes in patients with/without diabetes mellitus (DM). Methods and results: Utilizing the Asian Sudden Cardiac Death in HF (ASIAN-HF) registry, 5255 patients (mean age 59.6 ± 13.1, 78% men) with symptomatic HF with reduced ejection fraction (HFrEF) were stratified by DM status to address the research aims. Despite similar prevalence of DM between Asian men (43%) and women (42%), the odds of DM increased at lower body mass index in women vs. men (≥ 23 vs. ≥ 27.5 kg/m 2 , P interaction = 0.014). DM was more strongly related to chronic kidney disease in women vs. men [adjusted odds ratio (OR) 1.85, 95% confidence interval (CI) 1.33–2.57 vs. OR 1.32, 95% CI 1.11–1.56, P interaction = 0.009]. Sex also modified the relationship between DM and left ventricular geometry (P interaction = 0.003), whereby DM was associated with a more concentric left ventricular geometry in women than men. Women had lower quality of life than men (P < 0.001), in both DM and non-DM groups. DM was associated with worse composite outcomes at 1 year in women vs. men [hazard ratio (HR) 1.79, 95% CI 1.24–2.60 vs. HR 1.32, 95% CI 1.12–1.56; P interaction = 0.005). Conclusions: Asian women with HFrEF were more likely to have DM despite a lean body mass index, a greater burden of chronic kidney disease and more concentric left ventricular geometry, compared to men. Furthermore, DM confers worse quality of life, irrespective of sex, and a greater risk of adverse outcomes in women than men. These data underscore the need for sex-specific approaches to diabetes in patients with HF.
URI: http://repository.li.mahidol.ac.th/dspace/handle/123456789/51845
metadata.dc.identifier.url: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85058157463&origin=inward
ISSN: 18790844
13889842
Appears in Collections:Scopus 2019

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