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dc.contributor.authorChanchal Chandramoulien_US
dc.contributor.authorTiew Hwa Katherine Tengen_US
dc.contributor.authorWan Ting Tayen_US
dc.contributor.authorJonathan Yapen_US
dc.contributor.authorMichael R. MacDonalden_US
dc.contributor.authorJasper Trompen_US
dc.contributor.authorLimin Yanen_US
dc.contributor.authorBambang Siswantoen_US
dc.contributor.authorEugenio B. Reyesen_US
dc.contributor.authorTachapong Ngarmukosen_US
dc.contributor.authorCheuk Man Yuen_US
dc.contributor.authorChung Lieh Hungen_US
dc.contributor.authorInder Ananden_US
dc.contributor.authorA. Mark Richardsen_US
dc.contributor.authorLieng Hsi Lingen_US
dc.contributor.authorJudith G. Regensteineren_US
dc.contributor.authorCarolyn S.P. Lamen_US
dc.contributor.authorA. Mark Richardsen_US
dc.contributor.authorCarolyn S.P. Lamen_US
dc.contributor.authorInder Ananden_US
dc.contributor.authorChung Lieh Hungen_US
dc.contributor.authorLieng Hsi Lingen_US
dc.contributor.authorHoung Bang Liewen_US
dc.contributor.authorCalambur Narasimhanen_US
dc.contributor.authorSang Weon Parken_US
dc.contributor.authorEugenio Reyesen_US
dc.contributor.authorBambang B. Siswantoen_US
dc.contributor.authorWataru Shimizuen_US
dc.contributor.authorShu Zhangen_US
dc.contributor.otherManila Doctors Hospitalen_US
dc.contributor.otherCare Hospital Hyderabaden_US
dc.contributor.otherUniversitas Indonesiaen_US
dc.contributor.otherMackay Memorial Hospital Taiwanen_US
dc.contributor.otherUniversity of Colorado School of Medicineen_US
dc.contributor.otherNippon Medical Schoolen_US
dc.contributor.otherUniversity of Otagoen_US
dc.contributor.otherNational University of Singaporeen_US
dc.contributor.otherFaculty of Medicine, Ramathibodi Hospital, Mahidol Universityen_US
dc.contributor.otherVA Medical Centeren_US
dc.contributor.otherChangi General Hospitalen_US
dc.contributor.otherUniversity of Minnesota Medical Schoolen_US
dc.contributor.otherUniversity of Groningen, University Medical Center Groningenen_US
dc.contributor.otherNational Heart Centre, Singaporeen_US
dc.contributor.otherChinese University of Hong Kongen_US
dc.contributor.otherQueen Elizabeth Hospitalen_US
dc.contributor.otherCardiovascular Research Instituteen_US
dc.contributor.otherFuwai Cardiovascular Hospitalen_US
dc.contributor.otherSejong General Hospitalen_US
dc.identifier.citationEuropean Journal of Heart Failure. Vol.21, No.3 (2019), 297-307en_US
dc.description.abstract© 2018 The Authors. European Journal of Heart Failure © 2018 European Society of Cardiology Aims: To examine sex differences in clinical characteristics, echocardiographic features, quality of life and 1-year death or heart failure (HF) hospitalization outcomes in patients with/without diabetes mellitus (DM). Methods and results: Utilizing the Asian Sudden Cardiac Death in HF (ASIAN-HF) registry, 5255 patients (mean age 59.6 ± 13.1, 78% men) with symptomatic HF with reduced ejection fraction (HFrEF) were stratified by DM status to address the research aims. Despite similar prevalence of DM between Asian men (43%) and women (42%), the odds of DM increased at lower body mass index in women vs. men (≥ 23 vs. ≥ 27.5 kg/m 2 , P interaction = 0.014). DM was more strongly related to chronic kidney disease in women vs. men [adjusted odds ratio (OR) 1.85, 95% confidence interval (CI) 1.33–2.57 vs. OR 1.32, 95% CI 1.11–1.56, P interaction = 0.009]. Sex also modified the relationship between DM and left ventricular geometry (P interaction = 0.003), whereby DM was associated with a more concentric left ventricular geometry in women than men. Women had lower quality of life than men (P < 0.001), in both DM and non-DM groups. DM was associated with worse composite outcomes at 1 year in women vs. men [hazard ratio (HR) 1.79, 95% CI 1.24–2.60 vs. HR 1.32, 95% CI 1.12–1.56; P interaction = 0.005). Conclusions: Asian women with HFrEF were more likely to have DM despite a lean body mass index, a greater burden of chronic kidney disease and more concentric left ventricular geometry, compared to men. Furthermore, DM confers worse quality of life, irrespective of sex, and a greater risk of adverse outcomes in women than men. These data underscore the need for sex-specific approaches to diabetes in patients with HF.en_US
dc.rightsMahidol Universityen_US
dc.titleImpact of diabetes and sex in heart failure with reduced ejection fraction patients from the ASIAN-HF registryen_US
Appears in Collections:Scopus 2019

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