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Title: Asymptomatic natural human infections with the simian malaria parasites plasmodium cynomolgi and plasmodium knowlesi
Authors: Mallika Imwong
Wanassanan Madmanee
Kanokon Suwannasin
Chanon Kunasol
Thomas J. Peto
Rupam Tripura
Lorenz Von Seidlein
Chea Nguon
Chan Davoeung
Nicholas P.J. Day
Arjen M. Dondorp
Nicholas J. White
Mahidol University
Nuffield Department of Clinical Medicine
Provincial Health Department
National Center for Parasitology, Entomology and Malaria Control
Keywords: Medicine
Issue Date: 15-Feb-2019
Citation: Journal of Infectious Diseases. Vol.219, No.5 (2019), 695-702
Abstract: © The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. Background In Southeast Asia, Plasmodium knowlesi, a parasite of long-tailed macaques (Macaca fascicularis), is an important cause of human malaria. Plasmodium cynomolgi also commonly infects these monkeys, but only one naturally acquired symptomatic human case has been reported previously. Methods Malariometric studies involving 5422 subjects (aged 6 months to 65 years) were conducted in 23 villages in Pailin and Battambang, western Cambodia. Parasite detection and genotyping was conducted on blood samples, using high-volume quantitative PCR (uPCR). Results Asymptomatic malaria parasite infections were detected in 1361 of 14732 samples (9.2%). Asymptomatic infections with nonhuman primate malaria parasites were found in 21 individuals living close to forested areas; P. cynomolgi was found in 11, P. knowlesi was found in 8, and P. vivax and P. cynomolgi were both found in 2. Only 2 subjects were female, and 14 were men aged 20-40 years. Geometric mean parasite densities were 3604 parasites/mL in P. cynomolgi infections and 52488 parasites/mL in P. knowlesi infections. All P. cynomolgi isolates had wild-type dihydrofolate reductase genes, in contrast to the very high prevalence of mutations in the human malaria parasites. Asymptomatic reappearance of P. cynomolgi occurred in 2 subjects 3 months after the first infection. Conclusions Asymptomatic naturally acquired P. cynomolgi and P. knowlesi infections can both occur in humans. Clinical Trials Registration NCT01872702.
ISSN: 15376613
Appears in Collections:Scopus 2019

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