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Title: Mean platelet volume (Mpv) as a predictor of venous thromboembolism (Vte) in colorectal cancer
Authors: C. Wilasrusmee
J. Wongsereepatana
N. Poprom
S. Horsirimanont
C. Supsamutchai
J. Jirasiritham
B. Siribumrungwong
S. Phuwapraisirisan
Faculty of Medicine, Ramathibodi Hospital, Mahidol University
Faculty of Medicine, Thammasat University
Keywords: Medicine
Issue Date: 1-Feb-2019
Citation: Journal of the Medical Association of Thailand. Vol.102, No.2 (2019), S92-S95
Abstract: © JOURNAL OF THE MEDICAL ASSOCIATION OF THAILAND| 2019. Background: Platelet activity is a major devilish atherothrombotic events and cancer. Mean platelet volume (MPV), which is widely available as a routine parameter of the complete blood count, is a potentially useful biomarker of platelet activity in the setting of venous thrombosis. Recent studies showed that high-MPV levels are associated with an increase VTE risk in cancer patients. Objective: To investigate the role of MPV in VTE and colorectal-cancer. Materials and Methods: A retrospective study was performed to analyze differences of MPV between patients with VTE, VTE and colorectal-cancer, and control. We identified comparative studies that compared the effect of MPV in VTE from PubMed and Scopus databases up to December 2017. Two reviewers independently extracted data for meta-analysis. Differences in MPV were expressed as unstandardized mean difference. Results: Among 170 patients, 58-control, 54-VTE, and 58-VTE with colorectal-cancer, MPV was significantly higher in VTE groups. From 403 articles, 10 studies (5 cohorts and 5 case-controls) comprising 2,265 patients. MPV was significantly higher in those with VTE (mean difference 0.61 fL, 95% CI 0.34 to 0.88, p<0.001). Elevated MPV increased the relative risk of VTE (RR 1.319, 1.061 to 1.641, I2 = 82.5%). Conclusion: Our evidence suggests that elevated MPV is associated with VTE and VTE with colorectal-cancer. A mechanistic study and RCT are required in order to use antiplatelet therapy.
ISSN: 01252208
Appears in Collections:Scopus 2019

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