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Title: Antidiabetic effects of Maclura cochinchinensis (Lour.) corner heartwood extract
Authors: Savita Chewchinda
Nantakarn Leakaya
Hitoshi Sato
Vilasinee Hirunpanich Sato
Showa University
Mahidol University
Keywords: Medicine
Issue Date: 1-Jan-2019
Citation: Journal of Traditional and Complementary Medicine. (2019)
Abstract: © 2019 Center for Food and Biomolecules, National Taiwan University Background and aim: Maclura cochinchinensis (MC) (Lour.) heartwood extract have been used traditionally to treat diabetes in Thailand, but their mechanism of action has not been elucidated. Experimental procedure: This study investigated the effects of an aqueous heartwood extract of MC on α-glucosidase and α-amylase activities. Moreover, its antidiabetic effect was evaluated using an oral glucose tolerance test (OGTT) and a 28-day administration to streptozotocin (STZ)-nicotinamide (NA)-induced type 2 diabetic mice. Results: In both OGTT and the daily oral administration for 28 days in STZ-NA-induced type 2 diabetic mice models, the extract (1,000 mg/kg) significantly decreased fasting blood glucose. This hypoglycemic effect was explained by increased insulin levels and α-glucosidase inhibition (IC50:1.53 ± 0.03 μg/mL). Conclusion: This first study on the hypoglycemic activity of MC heartwood extract indicates that it could be a potential natural remedy for type 2 diabetes.
ISSN: 22254110
Appears in Collections:Scopus 2019

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