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Title: Pharmacokinetics and penetration of sitafloxacin into alveolar epithelial lining fluid in critically ill Thai patients with pneumonia
Authors: Taniya Paiboonvong
Wichit Nosoongnoen
Korbtham Sathirakul
Viratch Tangsujaritvijit
Jaipak Kaemapairoj
Pramote Tragulpiankit
Preecha Montakantikul
Faculty of Medicine, Ramathibodi Hospital, Mahidol University
Mahidol University
Keywords: Medicine
Issue Date: 1-Jan-2019
Citation: Antimicrobial Agents and Chemotherapy. Vol.63, No.10 (2019)
Abstract: Copyright © 2019 American Society for Microbiology. All Rights Reserved. Sitafloxacin showed potent activity against various respiratory pathogens. Blood and bronchoalveolar lavage (BAL) fluid samples were obtained from 12 subjects after a single oral dose of sitafloxacin 200 mg. The mean ± SD (median) maximum ratio of epithelial lining fluid (ELF) to unbound plasma concentration was 1.02 ± 0.58 (1.33). The penetration ratios based on the mean and median area under the curve from 0 to 8 h (AUC0 – 8) were 0.85 and 0.79 μg · h/ml, respectively. Sitafloxacin penetrates well into ELF in critically ill Thai patients with pneumonia. (This study has been registered in the Thai Clinical Trials Registry [TCTR] under registration no. TCTR20170222001.)
ISSN: 10986596
Appears in Collections:Scopus 2019

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