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Title: CMV-Reactive NK Cells in Pediatric Post-Hematopoietic Stem Cell Transplant
Authors: Nopporn Apiwattanakul
Suradej Hongeng
Usanarat Anurathapan
Samart Pakakasama
Supanart Srisala
Chompunuch Klinmalai
Borje S. Andersson
Faculty of Medicine, Ramathibodi Hospital, Mahidol University
University of Texas MD Anderson Cancer Center
Keywords: Medicine
Issue Date: 1-Jan-2019
Citation: Transplantation Proceedings. (2019)
Abstract: © 2019 Elsevier Inc. Background: Immune reconstitution of T cells has been proven to be a protective factor against cytomegalovirus (CMV) reactivation in patients post-hematopoietic stem cell transplant. Recently, more evidence has suggested that natural killer (NK) cells also play role in the protection against CMV reactivation in these patients. Methods: CMV-specific T cells and CMV-reactive NK cells from pediatric patients undergoing hematopoietic stem cell transplant were examined by flow cytometry. These cells were defined as cells producing interferon gamma (IFNγ) upon stimulation with CMV antigens. Results: This study demonstrated that NK cells reactive to CMV do exist in pediatric patients after stem cell transplant. These cells vigorously responded to stimulation with CMV peptides (pp65 and IE1) and to a lesser extent to CMV whole lysate by secretion of IFNγ. Patients with CMV reactivation tended to have less CMV-reactive NK cells than those without. Conclusion: Reconstitution of CMV-reactive NK cells, together with CMV-specific T cells, may play a role in the control of CMV infections in patients after stem cell transplant.
ISSN: 18732623
Appears in Collections:Scopus 2019

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