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|Title:||Isoforms of group 1 allergens from a tropical/ subtropical para grass (Urochloa mutica) display different levels of igE reactivity and cross-reactivity|
Faculty of Medicine, Siriraj Hospital, Mahidol University
|Citation:||European Annals of Allergy and Clinical Immunology. Vol.51, No.4 (2019), 174-185|
|Abstract:||© 2019, EDRA S.p.A. All rights reserved. Group 1 grass pollen allergens, or beta-expansins, are the most important major allergens from tropical/subtropical grasses. This study aimed to investigate the sequence similarity and immunoreactivity of group 1 allergens from para grass (Urochloa mutica). Three isoforms (Uro m 1.01, Uro m 1.02, and Uro m 1.03) were cloned from cDNA of para grass pollen. The acidic-neutral isoforms rUro m 1.01 and rUro m 1.02 could effectively inhibited beta-expansins in pollen extract of Bermuda and Johnson grasses, suggesting that these isoforms could be major cross-reacting allergens among these grasses. In contrast, the basic isoform rUro m 1.03 had limited IgE reactivity. Thus, group 1 allergens both acidic-neutral and basic isoforms could have markedly different IgE reactivity.|
|Appears in Collections:||Scopus 2019|
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