Please use this identifier to cite or link to this item:
|Title:||Association between smoking and risk of primary biliary cholangitis: A systematic review and meta-analysis|
Paul T. Kroner
Omar Y. Mousa
Frank J. Lukens
Denise M. Harnois
Mayo Medical School
Faculty of Medicine, Siriraj Hospital, Mahidol University
Mayo Clinic in Jacksonville, Florida
Bassett Medical Center
|Citation:||Journal of Gastrointestinal and Liver Diseases. Vol.28, No.2 (2019), 197-203|
|Abstract:||© 2019, Romanian Society of Gastroenterology. All rights reserved. Background & Aims: Studies have suggested that smokers may have a higher risk of primary biliary cholangitis (PBC) although the results have been inconsistent. This systematic review and meta-analysis aim to better characterize the risk of PBC among smokers by identifying all relevant studies and summarizing their results together. Methods: A comprehensive literature review was conducted using Embase and Pubmed/MEDLINE databases from inception to September 2018 to identify all studies which compared the risk of PBC among current, ever and former smokers to non-smokers. Effect estimates from each study were extracted and combined together using the random-effect, generic inverse variance method of DerSimonian and Laird. Results: Nine case-control studies with 21,577 participants met the eligibility criteria and were included in the meta-analysis. The risk of PBC among ever smokers was significantly higher than non-smokers with the pooled odds ratio (OR) of 1.31 (95% CI, 1.03-1.67; I2 89%). Subgroup analysis found that the risk was higher in both former smokers (pooled OR 1.36; 95% CI, 1.01-1.84; I2 75%) and current smokers (pooled OR 1.18; 95% CI, 0.94-1.50; I2 79%), although the latter did not reach statistical significance. Immunomodulatory and cytotoxic effect of cigarettes were the possible mechanisms behind this increased risk. Conclusions: A significantly increased risk of PBC among individuals who ever smoked was observed in this study, adding to the already long list of harmful health consequences of smoking.|
|Appears in Collections:||Scopus 2019|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.