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Title: Eicosapentaenoic acids enhance chemosensitivity through connexin 43 upregulation in murine melanoma models
Authors: Chih Jen Yang
Chi Te Kuo
Li Hsien Wu
Man Chin Chen
Christian Ronquillo Pangilinan
Naphichaya Phacharapiyangkul
Wangta Liu
Ya Huey Chen
Che Hsin Lee
Kaohsiung Medical University Chung-Ho Memorial Hospital
China Medical University Hospital Taichung
Mahidol University
Kaohsiung Medical University
National Sun Yat-Sen University Taiwan
China Medical University Taichung
National Cheng Kung University Medical College
Keywords: Medicine
Issue Date: 1-Jan-2019
Citation: International Journal of Medical Sciences. Vol.16, No.5 (2019), 636-643
Abstract: © Ivyspring International Publisher. Chemotherapy is now in common use for the treatment of tumors; however, with tumor growth retardation comes the severe side effects that occur after a chemotherapy cycle. Eicosapentaenoic acids (EPA) used in combination with chemotherapy has an additive effects and provides a rationale for using EPA in tandem with chemotherapy. To improve the efficacy and safety of this combination therapy, a further understanding that EPA modulates with the tumor microenvironment is necessary. Connexin 43 (Cx43) is involved in enhancing chemosensitivity that was suppressed in a tumor microenvironment. We aim to investigate the role of EPA in chemosensitivity in murine melanoma by inducing Cx43 expression. The dose-dependent upregulation of Cx43 expression and gap junction intercellular communication were observed in B16F10 cells after EPA treatment. Furthermore, EPA significantly increased the expression levels of mitogen-activated protein kinases (MAPK) signaling pathways. The EPA-induced Cx43 expression was reduced after MAPK inhibitors. Knockdown Cx43 in B16F10 cells reduced the therapeutic effects of combination therapy (EPA plus 5-Fluorouracil). Our results demonstrate that the treatment of EPA is a tumor induced Cx43 gap junction communication and enhances the combination of EPA and chemotherapeutic effects.
ISSN: 14491907
Appears in Collections:Scopus 2019

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