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Title: Antimicrobial activities of Suregada multiflora extracts against skin pathogens
Authors: Thunyanaratada Tangsri
Jaturong Pratuangdejkul
Suchitra Thongpraditchote
Veena Satitpatipan
Pongpan Siripong
วีณา สาธิตปัตติพันธ์
สุจิตรา ทองประดิษฐ์โชติ
จตุรงค์ ประเทืองเดชกุล
Mahidol University. Faculty of Pharmacy. Department of Microbiology
Mahidol University. Faculty of Pharmacy. Department of Physiology
Mahidol University. Faculty of Pharmacy. Department of Pharmacognosy
Department of Public Health and Human Services. National Cancer Institute
Keywords: Suregada multiflora;Khun-Thong Prayabaat;Antimicrobial activity
Issue Date: 2019
Abstract: Suregada multiflora A. Juss. is frequently used as one of herbal medicine in Thai traditional recipes for treating dermatological diseases; i.e. Yaw disease, leprosy, eczema, psoriasis, and skin infection diseases. This research aimed to study antimicrobial activities of S. multiflora extracts which were carried out by serial manner of extraction (hexane, dichloromethane, and 95% ethanol) and the traditional extraction (decoction and maceration with aqueous and 95% ethanol, respectively). The Minimal Inhibitory Concentration (MIC) were determined by resazurin-based broth microdilution assay. The Minimal Bactericidal Concentration (MBC) were subsequently determined using drop-plate method. For Gram– positive bacteria and fungi, hexane extract of S. multiflora exhibited antimicrobial activity against Staphylococus epidermidis DMST 15471, Staphylococcus aureus ATCC 25923, Methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300, Cutibacterium acnes DMST 14916, and Candida albicans DMST 5815 with the MIC values of 0.1563, 0.625, 0.625, 0.625, and 1.25 mg/mL, respectively. While, the MBC values of S. multiflora hexane crude extract were 0.3125, 2.5, and 5 mg/mL for S. epidermidis, C. acnes, and C. albicans, respectively. For S. multiflora dichloromethane crude extract, the MIC values of 0.0781, 0.625, 0.625, 1.25 and 2.5 mg/mL were respectively found for S. epidermidis, S. aureus, C. acnes, C. albicans, and MRSA, however, its MBC values were detected only in S. epidermidis and C. acnes with 0.625 and 1.25 mg/mL, respectively. From this study, the extracts of S. multiflora, revealed the in vitro potential antimicrobial activities against some skin pathogens which supports Thai traditional remedies use of S. multiflora for treatment of skin disease.
Description: The 1st Pharmaceutical Sciences Asia Conference 2019 Theme : Pharmaceutical Sciences toward Health Innovation in the Disruptive Era. Bangkok Midtown Hotel, Thailand. August 22, 2019, page 53-58
Appears in Collections:PY-Proceeding Document

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