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Title: YAP-depleted iPSC MUSIi012-A-2 maintained all normal stem cell characteristics
Authors: Chanchao Lorthongpanich
Chuti Laowtammathron
Nittaya Jiamvoraphong
Pimonwan Srisook
Pimjai Chingsuwanrote
Phatchanat Klaihmon
Nattaya Damkham
Papussorn Terbto
Supaporn Waeteekul
Yaowalak U-pratya
Surapol Issaragrisil
Faculty of Medicine, Siriraj Hospital, Mahidol University
Wattanosoth Hospital
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Mar-2020
Citation: Stem Cell Research. Vol.43, (2020)
Abstract: © 2020 The Author(s) Yes-associated protein (YAP) is an important transcriptional coactivator in the Hippo signaling pathway. Using CRISPR/Cas9 technology, we established a stable YAP-knockdown (YAP-KD) induced pluripotent stem cell (iPSC) from the MUSIi012-A cell line. The YAP-KD iPSC MUSIi012-A-2 maintained the pluripotent phenotype, the ability to differentiate into all three embryonic germ layers, and it maintained the normal karyotype.
ISSN: 18767753
Appears in Collections:Scopus 2020

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