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dc.contributor.authorMonpat Chamnanphonen_US
dc.contributor.authorAndrea Gaedigken_US
dc.contributor.authorApichaya Puangpetchen_US
dc.contributor.authorEkawat Pasomsuben_US
dc.contributor.authorWasun Chantratitaen_US
dc.contributor.authorRhea J. Longleyen_US
dc.contributor.authorJetsumon Sattabongkoten_US
dc.contributor.authorPajaree Chariyavilaskulen_US
dc.contributor.authorChonlaphat Sukasemen_US
dc.contributor.otherChulalongkorn Universityen_US
dc.contributor.otherWalter and Eliza Hall Institute of Medical Researchen_US
dc.contributor.otherUniversity of Melbourneen_US
dc.contributor.otherFaculty of Medicine, Ramathibodi Hospital, Mahidol Universityen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherUniversity of Missouri-Kansas Cityen_US
dc.date.accessioned2020-03-26T04:34:50Z-
dc.date.available2020-03-26T04:34:50Z-
dc.date.issued2020-01-01en_US
dc.identifier.citationPharmacogenomics and Personalized Medicine. Vol.13, (2020), 1-12en_US
dc.identifier.issn11787066en_US
dc.identifier.other2-s2.0-85078285036en_US
dc.identifier.urihttp://repository.li.mahidol.ac.th/dspace/handle/123456789/53614-
dc.description.abstract© 2020 Chamnanphon et al. Purpose: Pharmacogenes have an influence on biotransformation pathway and clinical outcome of primaquine and chloroquine which are often prescribed to treat Plasmodium vivax infection. Genetic variation may impact enzyme activity and/or transporter function and thereby contribute to relapse. The aim of the study was to assess allele, genotype frequencies and the association between pharmacogenes variation and primaquine response in Thai patients infected with Plasmodium vivax. Patients and Methods: Fifty-one patients were genotyped for 74 variants in 18 genes by Sequenom MassARRAY® and Taqman® SNP Real-Time PCR. Results: SNP frequencies were not significantly different between relapse (n=4) and non-relapse (n=47) patients. However, the CYP2C19 c.681G>A, the frequency of the A-allele that defines the non-functional CYP2C19*2 haplotype was significantly higher compared to the G-allele (OR=5.14, p=0.021). Patients heterozygous for ABCG2 c.421C>A had a higher odds ratio (OR=8.75, p=0.071) and the frequency of the G-allele of UGT2B7 c.372G>A was higher compared to the A-allele (OR=3.75, p=0.081). CYP2C19, ABCG2 and UGT2B7 emerged as potential high priority genes. Conclusion: Decreased activity of CYP2C19, ABCG2 and UGT2B7 in combination with CYP2D6 intermediate or poor metabolizer status may expose patients to a higher risk of Plasmodium vivax relapse. Further investigations are warranted to substantiate these findings.en_US
dc.rightsMahidol Universityen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85078285036&origin=inwarden_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titlePharmacogene variation in Thai Plasmodium vivax relapse patients treated with a combination of primaquine and chloroquineen_US
dc.typeArticleen_US
dc.rights.holderSCOPUSen_US
dc.identifier.doi10.2147/PGPM.S201007en_US
dc.identifier.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85078285036&origin=inwarden_US
Appears in Collections:Scopus 2020

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