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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/53618
Title: Global Retinoblastoma Presentation and Analysis by National Income Level
Authors: Ido Didi Fabian
Elhassan Abdallah
Shehu U. Abdullahi
Rula A. Abdulqader
Sahadatou Adamou Boubacar
Dupe S. Ademola-Popoola
Adedayo Adio
Armin R. Afshar
Priyanka Aggarwal
Ada E. Aghaji
Alia Ahmad
Marliyanti N.R. Akib
Lamis Al Harby
Mouroge H. Al Ani
Aygun Alakbarova
Silvia Alarcón Portabella
Safaa A.F. Al-Badri
Ana Patricia A. Alcasabas
Saad A. Al-Dahmash
Amanda Alejos
Ernesto Alemany-Rubio
Amadou I. Alfa Bio
Yvania Alfonso Carreras
Christiane Al-Haddad
Hamoud H.Y. Al-Hussaini
Amany M. Ali
Donjeta B. Alia
Mazin F. Al-Jadiry
Usama Al-Jumaly
Hind M. Alkatan
Charlotta All-Eriksson
Ali A.R.M. Al-Mafrachi
Argentino A. Almeida
Khalifa M. Alsawidi
Athar A.S.M. Al-Shaheen
Entissar H. Al-Shammary
Primawita O. Amiruddin
Romanzo Antonino
Nicholas J. Astbury
Hatice T. Atalay
La Ongsri Atchaneeyasakul
Rose Atsiaya
Taweevat Attaseth
Than H. Aung
Silvia Ayala
Baglan Baizakova
Julia Balaguer
Ruhengiz Balayeva
Walentyna Balwierz
Honorio Barranco
Covadonga Bascaran
Maja Beck Popovic
Raquel Benavides
Sarra Benmiloud
Nissrine Bennani Guebessi
Rokia C. Berete
Jesse L. Berry
Anirban Bhaduri
Sunil Bhat
Shelley J. Biddulph
Eva M. Biewald
Nadia Bobrova
Marianna Boehme
H. C. Boldt
Maria Teresa B.C. Bonanomi
Norbert Bornfeld
Gabrielle C. Bouda
Hédi Bouguila
Amaria Boumedane
Rachel C. Brennan
Bénédicte G. Brichard
Jassada Buaboonnam
Patricia Calderón-Sotelo
Doris A. Calle Jara
Jayne E. Camuglia
Miriam R. Cano
Michael Capra
Nathalie Cassoux
Guilherme Castela
Luis Castillo
Jaume Català-Mora
Guillermo L. Chantada
Shabana Chaudhry
Sonal S. Chaugule
Argudit Chauhan
Bhavna Chawla
Violeta S. Chernodrinska
Faraja S. Chiwanga
Tsengelmaa Chuluunbat
Krzysztof Cieslik
Ruellyn L. Cockcroft
Codruta Comsa
Zelia M. Correa
Maria G. Correa Llano
Timothy W. Corson
Kristin E. Cowan-Lyn
Monika Csóka
Xuehao Cui
Isac V. Da Gama
Wantanee Dangboon
Hawler Medical University
Dr. Rajendra Prasad Centre for Ophthalmic Sciences
Filatov Institute of Eye Diseases and Tissue Therapy
Instytut "Pomnik - Centrum Zdrowia Dziecka"
University of Tripoli
University Hospital Centre Tirana
Centre Hospitalier Universitaire Yalgado Ouedraogo
Hospital Nacional de Niños Dr. Carlos Sáenz Herrera
Centro Hospitalario Pereira Rossell
Muhimbili National Hospital
University of the Philippines Manila
Baghdad Teaching Hospital
University of Baghdad
Children's Hospital Lahore
Université de Tunis El Manar, Institut Hedi Raies d'ophtalmologie de Tunis
Calcutta Medical Research Institute
American University of Beirut Medical Center
King Edward Medical University Lahore
Hospital Universitari i Politècnic La Fe
London School of Hygiene & Tropical Medicine
University of Port Harcourt
University of Nigeria
Shanghai Jiao Tong University
Semmelweis Egyetem
Indiana University-Purdue University Indianapolis
University of Iowa
University of California, San Francisco
Centre Hospitalier Universitaire Vaudois
Uniwersytet Jagielloński Collegium Medicum
University of Louisville
Starship Children's Health
Our Lady's Hospital for Sick Children
Centre Hospitalier Universitaire Ibn-Rochd
St. Jude Children's Research Hospital
Centro Hospitalar e Universitário de Coimbra
IRCCS Ospedale Pediatrico Bambino Gesù
University of Cincinnati College of Medicine
Moorfields Eye Hospital NHS Foundation Trust
University of Witwatersrand
Faculty of Medicine, Ramathibodi Hospital, Mahidol University
Centre Hospitalier Universitaire Hassan II
Keck School of Medicine of USC
Gazi Üniversitesi
King Saud University
Cliniques Universitaires Saint-Luc
Hospital Universitari Vall d'Hebron
Institutul Oncologic Prof. Dr. Alexandru Trestioreanu Bucuresti
University Hospital Alexandrovska
Faculty of Medicine, Siriraj Hospital, Mahidol University
University of Ilorin
Banaras Hindu University
Universidade de Sao Paulo - USP
Universitäts Klinikum Essen und Medizinische Fakultät
Prince of Songkla University
Tel Aviv University
Consejo Nacional de Investigaciones Científicas y Técnicas
Bayero University
Fundacion Hospital de Pediatria Professor Dr. Juan P. Garrahan
Assiut University
Imam Hussein Cancer Center
Etablissement Hospitaliere Specialise Emir Abdelkader CEA Service d'Oncologie Pediatrique
Scientific Center of Pediatrics and Pediatric Surgery
Mohammed v University
Université Paris Descartes
Queensland Children's Hospital
Basra Specialty Hospital
National Center for Maternal and Child Health
University of Medicine 1
Central Hospital Quelimane
Ibn Al-Haitham Teaching Eye Hospital
University of Parakou
PBMA's H. V. Desai Eye Hospital
St. Damien Pediatric Hospital
Teaching Hospital of Treichville
National Centre of Ophthalmology Named after Acad. Zarifa Aliyeva
Beira Central Hospital
Instituto Cubano de Oftalmología Ramón Pando Ferrer
Hospital Sant Joan de Déu
Ministerio de Salud Pública
St Erik Eye Hospital
National Oncology Centre
Hospital del Niño Dr. Francisco de Icaza Bustamante
Retina Consultants of Houston
Unidad Nacional de Oncología Pediátrica
Lighthouse for Christ Eye Centre
Cicendo Eye Hospital
National Hospital of Niamey
Bustamante Hospital for Children
Hospital Infantil Manuel de Jesus Rivera
Keywords: Biochemistry, Genetics and Molecular Biology;Medicine
Issue Date: 1-Jan-2020
Citation: JAMA Oncology. (2020)
Abstract: © 2020 Cambridge University Press. All rights reserved. Importance: Early diagnosis of retinoblastoma, the most common intraocular cancer, can save both a child's life and vision. However, anecdotal evidence suggests that many children across the world are diagnosed late. To our knowledge, the clinical presentation of retinoblastoma has never been assessed on a global scale. Objectives: To report the retinoblastoma stage at diagnosis in patients across the world during a single year, to investigate associations between clinical variables and national income level, and to investigate risk factors for advanced disease at diagnosis. Design, Setting, and Participants: A total of 278 retinoblastoma treatment centers were recruited from June 2017 through December 2018 to participate in a cross-sectional analysis of treatment-naive patients with retinoblastoma who were diagnosed in 2017. Main Outcomes and Measures: Age at presentation, proportion of familial history of retinoblastoma, and tumor stage and metastasis. Results: The cohort included 4351 new patients from 153 countries; the median age at diagnosis was 30.5 (interquartile range, 18.3-45.9) months, and 1976 patients (45.4%) were female. Most patients (n = 3685 [84.7%]) were from low- A nd middle-income countries (LMICs). Globally, the most common indication for referral was leukocoria (n = 2638 [62.8%]), followed by strabismus (n = 429 [10.2%]) and proptosis (n = 309 [7.4%]). Patients from high-income countries (HICs) were diagnosed at a median age of 14.1 months, with 656 of 666 (98.5%) patients having intraocular retinoblastoma and 2 (0.3%) having metastasis. Patients from low-income countries were diagnosed at a median age of 30.5 months, with 256 of 521 (49.1%) having extraocular retinoblastoma and 94 of 498 (18.9%) having metastasis. Lower national income level was associated with older presentation age, higher proportion of locally advanced disease and distant metastasis, and smaller proportion of familial history of retinoblastoma. Advanced disease at diagnosis was more common in LMICs even after adjusting for age (odds ratio for low-income countries vs upper-middle-income countries and HICs, 17.92 [95% CI, 12.94-24.80], and for lower-middle-income countries vs upper-middle-income countries and HICs, 5.74 [95% CI, 4.30-7.68]). Conclusions and Relevance: This study is estimated to have included more than half of all new retinoblastoma cases worldwide in 2017. Children from LMICs, where the main global retinoblastoma burden lies, presented at an older age with more advanced disease and demonstrated a smaller proportion of familial history of retinoblastoma, likely because many do not reach a childbearing age. Given that retinoblastoma is curable, these data are concerning and mandate intervention at national and international levels. Further studies are needed to investigate factors, other than age at presentation, that may be associated with advanced disease in LMICs.
URI: http://repository.li.mahidol.ac.th/dspace/handle/123456789/53618
metadata.dc.identifier.url: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85081545321&origin=inward
ISSN: 23742445
23742437
Appears in Collections:Scopus 2020

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