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Title: A population of proinflammatory T cells coexpresses αβ and γδ T cell receptors in mice and humans
Authors: Sarah C. Edwards
Caroline E. Sutton
Kristin Ladell
Emma J. Grant
James E. McLaren
Fiona Roche
Pradyot Dash
Nopporn Apiwattanakul
Walid Awad
Kelly L. Miners
Stephen J. Lalor
Julie C. Ribot
Song Baik
Barry Moran
Aoife McGinley
Valerie Pivorunas
Lori Dowding
Michael Macoritto
Jesus Paez-Cortez
Anthony Slavin
Graham Anderson
Bruno Silva-Santos
Karsten Hokamp
David A. Price
Paul G. Thomas
Rachel M. McLoughlin
Kingston H.G. Mills
Cardiff University
University of Lisbon Faculty of Medicine, Institute of Molecular Medicine
St. Jude Children's Research Hospital
University of Birmingham
Monash University
Faculty of Medicine, Ramathibodi Hospital, Mahidol University
Trinity College Dublin
Keywords: Immunology and Microbiology;Medicine
Issue Date: 4-May-2020
Citation: The Journal of experimental medicine. Vol.217, No.5 (2020)
Abstract: © 2020 Edwards et al. T cells are classically recognized as distinct subsets that express αβ or γδ TCRs. We identify a novel population of T cells that coexpress αβ and γδ TCRs in mice and humans. These hybrid αβ-γδ T cells arose in the murine fetal thymus by day 16 of ontogeny, underwent αβ TCR-mediated positive selection into CD4+ or CD8+ thymocytes, and constituted up to 10% of TCRδ+ cells in lymphoid organs. They expressed high levels of IL-1R1 and IL-23R and secreted IFN-γ, IL-17, and GM-CSF in response to canonically restricted peptide antigens or stimulation with IL-1β and IL-23. Hybrid αβ-γδ T cells were transcriptomically distinct from conventional γδ T cells and displayed a hyperinflammatory phenotype enriched for chemokine receptors and homing molecules that facilitate migration to sites of inflammation. These proinflammatory T cells promoted bacterial clearance after infection with Staphylococcus aureus and, by licensing encephalitogenic Th17 cells, played a key role in the development of autoimmune disease in the central nervous system.
ISSN: 15409538
Appears in Collections:Scopus 2020

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