Simple jQuery Dropdowns
Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/53709
Title: Prevalence of group a streptococcus in primary care patients and the utility of c-reactive protein and clinical scores for its identification in Thailand
Authors: Rachel Greer
Thomas Althaus
Clare Ling
Daranee Intralawan
Supalert Nedsuwan
Janjira Thaipadungpanit
Tri Wangrangsimakul
Christopher Butler
Nicolas Day
Yoel Lubell
Chiang Rai Regional Hospital
University of Oxford
Mahidol University
Nuffield Department of Clinical Medicine
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Jan-2020
Citation: American Journal of Tropical Medicine and Hygiene. Vol.102, No.2 (2020), 377-383
Abstract: © 2020 by The American Society of Tropical Medicine and Hygiene. Pharyngitis is usually caused by a viral infection for which antibiotics are often unnecessarily prescribed, adding to the burden of antimicrobial resistance. Identifying who needs antibiotics is challenging; microbiological confirmation and clinical scores are used but have limitations. In a cross-sectional study nested within a randomized controlled trial, we estimated the prevalence and antibiotic susceptibility profiles of group A Streptococcus (GAS) in patients presenting to primary care with a sore throat and fever in northern Thailand. We then evaluated the use of C-reactive protein (CRP) and clinical scores (Centor and FeverPAIN) to identify the presence of GAS. One hundred sixty-nine patients were enrolled, of whom 35 (20.7%) had β-hemolytic Streptococci (BHS) isolated from throat swab culture, and 11 (6.5%) had GAS. All GAS isolates were sensitive to penicillin G. The median CRP of those without BHS isolation was 10 mg/L (interquartile range [IQR] ≤ 8-18), compared with 18 mg/L (IQR 9-71, P = 0.0302) for those with GAS and 14 mg/L (IQR ≤ 8-38, P = 0.0516) for those with any BHS isolated. However, there were no significant relationships betweenCRP> 8mg/L (P = 0.112),Centor ≥ 3 (P = 0.212), and FeverPAIN ≥ 4 (P = 1.000), and the diagnosis of GAS compared with no BHS isolation. Identifying who requires antibiotics for pharyngitis remains challenging and necessitates further larger studies. C-reactive protein testing alone, although imperfect, can reduce prescribing compared with routine care. Targeted CRP testing through clinical scoringmay be themost cost-effective approach to ruling out GAS infection.
URI: http://repository.li.mahidol.ac.th/dspace/handle/123456789/53709
metadata.dc.identifier.url: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85079076159&origin=inward
ISSN: 00029637
Appears in Collections:Scopus 2020

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.