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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/53736
Title: Lung microbiota predict clinical outcomes in critically ill patients
Authors: Robert P. Dickson
Marcus J. Schultz
Tom Van Der Poll
Laura R. Schouten
Nicole R. Falkowski
Jenna E. Luth
Michael W. Sjoding
Christopher A. Brown
Rishi Chanderraj
Gary B. Huffnagle
Lieuwe D.J. Bos
University of Michigan Medical School
Mahidol University
Universiteit van Amsterdam
Amsterdam UMC - University of Amsterdam
Michigan Center for Integrative Research in Critical Care
Keywords: Medicine
Issue Date: 1-Mar-2020
Citation: American Journal of Respiratory and Critical Care Medicine. Vol.201, No.5 (2020), 555-563
Abstract: © 2020 by the American Thoracic Society. Rationale: Recent studies have revealed that, in critically ill patients, lung microbiota are altered and correlate with alveolar inflammation. The clinical significance of altered lung bacteria in critical illness is unknown. Objectives: To determine if clinical outcomes of critically ill patients are predicted by features of the lung microbiome at the time of admission. Methods: We performed a prospective, observational cohort study in an ICU at a university hospital. Lung microbiota were quantified and characterized using droplet digital PCR and bacterial 16S ribosomal RNA gene quantification and sequencing. Primary predictors were the bacterial burden, community diversity, and community composition of lung microbiota. The primary outcome was ventilatorfree days, determined at 28 days after admission. Measurements and Main Results: Lungs of 91 critically ill patients were sampled using miniature BAL within 24 hours of ICU admission. Patients with increased lung bacterial burden had fewer ventilator-free days (hazard ratio, 0.43; 95% confidence interval, 0.21-0.88), which remained significant when the analysis was controlled for pneumonia and severity of illness. The community composition of lung bacteria predicted ventilator-free days (P = 0.003), driven by the presence of gutassociated bacteria (e.g., species of the Lachnospiraceae and Enterobacteriaceae families). Detection of gut-associated bacteria was also associated with the presence of acute respiratory distress syndrome. Conclusions: Key features of the lung microbiome (bacterial burden and enrichment with gut-associated bacteria) predict outcomes in critically ill patients. The lung microbiome is an understudied source of clinical variation in critical illness and represents a novel therapeutic target for the prevention and treatment of acute respiratory failure.
URI: http://repository.li.mahidol.ac.th/dspace/handle/123456789/53736
metadata.dc.identifier.url: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85080041449&origin=inward
ISSN: 15354970
1073449X
Appears in Collections:Scopus 2020

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