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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/53775
Title: PET/CT features of extrapulmonary tuberculosis at first clinical presentation: A cross-sectional observational <sup>18</sup>F-FDG imaging study across six countries
Authors: Jamshed Bomanji
Rajnish Sharma
Bhagwant R. Mittal
Sanjay Gambhir
Ahmad Qureshy
Shamim M.F. Begum
Diana Paez
Mike Sathekge
Mariza Vorster
Dragana Sobic Saranovic
Pawana Pusuwan
Vera Mann
Sobhan Vinjamuri
Alimuddin Zumla
Thomas N.B. Pascual
University of Belgrade
NHS Foundation Trust
Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow
Osterreichische Institut fur Internationale Politik
UCL
Universiteit van Pretoria
International Atomic Energy Agency, Vienna
Faculty of Medicine, Siriraj Hospital, Mahidol University
Royal Liverpool and Broadgreen University Hospitals NHS Trust
Institute of Nuclear Medicine and Allied Sciences India
Postgraduate Institute of Medical Education &amp; Research, Chandigarh
National Institute of Nuclear Medicine and Allied Sciences (NINMAS)
Institute of Nuclear Medicine and Oncology (INMOL)
Keywords: Medicine
Issue Date: 1-Feb-2020
Citation: European Respiratory Journal. Vol.55, No.2 (2020)
Abstract: Copyright © ERS 2020 Background: A large proportion of the huge global burden of extrapulmonary tuberculosis (EPTB) cases are treated empirically without accurate definition of disease sites and extent of multi-organ disease involvement. Positron emission tomography (PET) imaging using 2-deoxy-2-(fluorine-18) fluoro-Dglucose (18F-FDG) in tuberculosis could be a useful imaging technique for localising disease sites and extent of disease. Methods: We conducted a study of HIV-negative adult patients with a new clinical diagnosis of EPTB across eight centres located in six countries: India, Pakistan, Thailand, South Africa, Serbia and Bangladesh, to assess the extent of disease and common sites involved at first presentation. 18F-FDG PET/ computed tomography (CT) scans were performed within 2 weeks of presentation. Findings: 358 patients with EPTB (189 females; 169 males) were recruited over 45 months, with an age range of 18–83 years (females median 30 years; males median 38 years). 350 (98%) out of 358 patients (183 female, 167 male) had positive scans. 118 (33.7%) out of 350 had a single extrapulmonary site and 232 (66.3%) out of 350 had more than one site (organ) affected. Lymph nodes, skeleton, pleura and brain were common sites. 100 (28%) out of 358 EPTB patients had 18F-FDG PET/CT-positive sites in the lung. 110 patients were 18F-FDG PET/CT-positive in more body sites than were noted clinically at first presentation and 160 patients had the same number of positive body sites. Interpretation: 18F-FDG PET/CT scan has potential for further elucidating the spectrum of disease, pathogenesis of EPTB and monitoring the effects of treatment on active lesions over time, and requires longitudinal cohort studies, twinned with biopsy and molecular studies.
URI: http://repository.li.mahidol.ac.th/dspace/handle/123456789/53775
metadata.dc.identifier.url: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85080829825&origin=inward
ISSN: 13993003
09031936
Appears in Collections:Scopus 2020

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