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dc.contributor.authorWilanee Dechkhajornen_US
dc.contributor.authorSurachet Benjathummaraken_US
dc.contributor.authorSupattra Glaharnen_US
dc.contributor.authorUrai Chaisrien_US
dc.contributor.authorParnpen Viriyavejakulen_US
dc.contributor.authorYaowapa Maneeraten_US
dc.contributor.otherMahidol Universityen_US
dc.date.accessioned2020-03-26T05:18:42Z-
dc.date.available2020-03-26T05:18:42Z-
dc.date.issued2020-12-01en_US
dc.identifier.citationScientific Reports. Vol.10, No.1 (2020)en_US
dc.identifier.issn20452322en_US
dc.identifier.other2-s2.0-85080919237en_US
dc.identifier.urihttp://repository.li.mahidol.ac.th/dspace/handle/123456789/53927-
dc.description.abstract© 2020, The Author(s). Previous studies have reported activation of the B cell-activating factor (BAFF)/a proliferation-inducing ligand (APRIL) system in T independent immunity against malaria infection. Plasmodium falciparum (P. falciparum) infected animal model is not feasible. Therefore, little is known about the occurrence of BAFF/APRIL system and changes in falciparum lymphoid tissues. This study aimed to investigate the expression of BAFF/APRIL system components in lymphoid tissues from P. falciparum infected patients. Spleen and lymph node samples from 14 patients were collected at autopsy. Normal spleens and bacterially infected tonsils served as controls. The protein and/or mRNA expression of BAFF/APRIL and their cognate receptors, BAFF-R, TACI and BCMA, were determined by immunohistochemistry and RT-qPCR, respectively. The spleens of the patients exhibited significantly higher BAFF-R protein expression than normal spleens. Although without appropriate control, BCMA protein was markedly observed only in the lymph nodes. BAFF and BCMA mRNA levels were also significantly elevated in the spleen tissues of the patients compared with normal spleens. The overall BAFF-R protein levels in the lymphoid tissues of the patients correlated positively with parasitaemia. These findings are the first to confirm that BAFF/APRIL system activation in lymphoid tissues and is positively correlated with the parasitaemia levels in falciparum malaria.en_US
dc.rightsMahidol Universityen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85080919237&origin=inwarden_US
dc.subjectMultidisciplinaryen_US
dc.titleThe activation of BAFF/APRIL system in spleen and lymph nodes of Plasmodium falciparum infected patientsen_US
dc.typeArticleen_US
dc.rights.holderSCOPUSen_US
dc.identifier.doi10.1038/s41598-020-60763-3en_US
dc.identifier.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85080919237&origin=inwarden_US
Appears in Collections:Scopus 2020

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