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dc.contributor.authorAtitaya Hitakarunen_US
dc.contributor.authorSarawut Khongwichiten_US
dc.contributor.authorNitwara Wikanen_US
dc.contributor.authorSittiruk Roytrakulen_US
dc.contributor.authorSutee Yoksanen_US
dc.contributor.authorSupoth Rajakamen_US
dc.contributor.authorAndrew D. Davidsonen_US
dc.contributor.authorDuncan R. Smithen_US
dc.contributor.otherUniversity of Bristolen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherThailand National Center for Genetic Engineering and Biotechnologyen_US
dc.identifier.citationScientific Reports. Vol.10, No.1 (2020)en_US
dc.description.abstract© 2020, The Author(s). Many mosquito transmitted viruses of the genera Alphavirus and Flavivirus are human pathogens of significant concern, and there is currently no specific antiviral for any member of these two genera. This study sought to investigate the broad utility of orlistat (tetrahydrolipstatin) in reducing virus infection for several mosquito borne viruses including flaviviruses (dengue virus (DENV; nine isolates analyzed), Japanese encephalitis virus (JEV; one isolate analyzed) and Zika virus (ZIKV; 2 isolates analyzed)) as well as an alphavirus (chikungunya virus; CHIKV; 2 isolates analyzed). Three different treatment regimens were evaluated, namely pre-treatment (only), post-treatment (only) and pre- and post-treatment, and three factors were evaluated, namely level of infection, virus titer and genome copy number. Results showed that all three treatment modalities were able to significantly reduce virus titer for all viruses investigated, with the exception of three isolates of DENV in the pre-treatment only regimen. Pre- and post-treatment was more effective in reducing the level of infection and genome copy number of all viruses investigated than either pre-treatment or post-treatment alone. Collectively, these results suggest orlistat has potential as a broad-spectrum agent against multiple mosquito transmitted viruses.en_US
dc.rightsMahidol Universityen_US
dc.titleEvaluation of the antiviral activity of orlistat (tetrahydrolipstatin) against dengue virus, Japanese encephalitis virus, Zika virus and chikungunya virusen_US
Appears in Collections:Scopus 2020

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