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dc.contributor.authorIyapa Palangen_US
dc.contributor.authorBoonsirm Withyachumnarnkulen_US
dc.contributor.authorSaengchan Senapinen_US
dc.contributor.authorWanna Sirimanapongen_US
dc.contributor.authorRapeepun Vanichviriyakiten_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherThailand National Center for Genetic Engineering and Biotechnologyen_US
dc.contributor.otherPrince of Songkla Universityen_US
dc.contributor.otherAquaAcademy Farmen_US
dc.identifier.citationMicroscopy Research and Technique. (2020)en_US
dc.description.abstract© 2020 Wiley Periodicals, Inc. One of the clinical manifestations of streptococcosis is swimming errors of the infected fish, which is likely caused by lesions in the brain. As most studies described brain histopathology in streptococcosis as meningitis, with a limited description of lesions in the whole brain, the aim of this study was therefore to explore histopathology of the whole brain of red tilapia experimentally infected with Streptococcus agalactiae serotype III. Transcripts relating to motoneuron functions and inflammatory responses were also investigated. In the S. agalactiae-infected fish, the parenchyma of the whole brain and its associated meninx primitiva were found to be markedly infiltrated by mononuclear cells and Gram-positive cocci. Hemorrhage, neuronal necrosis, and localized spongiform histopathology were observed, especially within the midbrain and the cerebellum. The lesion was observed in the medial longitudinal fasciculus and its nucleus. Expressions of the transcripts CD166, GAP43, SMN, and SV2B of the infected fish did not change, while those of IL-1β and TNF-α were significantly upregulated. It is likely that S. agalactiae cause extensive damage to the fish brain, especially in areas that control swimming activities, through both direct invasion of the bacteria and acute inflammatory responses of the brain resident macrophages, or microglia.en_US
dc.rightsMahidol Universityen_US
dc.subjectHealth Professionsen_US
dc.subjectPhysics and Astronomyen_US
dc.titleBrain histopathology in red tilapia Oreochromis sp. experimentally infected with Streptococcus agalactiae serotype IIIen_US
Appears in Collections:Scopus 2020

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