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Title: Tools to accelerate falciparum malaria elimination in Cambodia: A meeting report
Authors: Dysoley Lek
James J. Callery
Chea Nguon
Mark Debackere
Siv Sovannaroth
Rupam Tripura
Marius Wojnarski
Patrice Piola
Soy Ty Khean
Kylie Manion
Sokomar Nguon
Amber Kunkel
Lieven Vernaeve
Thomas J. Peto
Emily Dantzer
Chan Davoeung
William Etienne
Arjen M. Dondorp
Luciano Tuseo
Lorenz Von Seidlein
Jean Olivier Guintran
University Research Co., LLC
Institut Pasteur du Cambodge
London School of Hygiene & Tropical Medicine
Organisation Mondiale de la Santé
University of Oxford
University of California, San Francisco
Armed Forces Research Institute of Medical Sciences, Thailand
Mahidol University
Institut Pasteur, Paris
Malaria Consortium
Centre for Parasitology, Entomology and Malaria Control
Provincial Health Department
Keywords: Immunology and Microbiology;Medicine
Issue Date: 15-Apr-2020
Citation: Malaria Journal. Vol.19, No.1 (2020)
Abstract: © 2020 The Author(s). Cambodia targets malaria elimination by 2025. Rapid elimination will depend on successfully identifying and clearing malaria foci linked to forests. Expanding and maintaining universal access to early diagnosis and effective treatment remains the key to malaria control and ultimately malaria elimination in the Greater Mekong Subregion (GMS) in the foreseeable future. Mass Drug Administration (MDA) holds some promise in the rapid reduction of Plasmodium falciparum infections, but requires considerable investment of resources and time to mobilize the target communities. Furthermore, the most practical drug regimen for MDA in the GMS-three rounds of DHA/piperaquine-has lost some of its efficacy. Mass screening and treatment benefits asymptomatic P. falciparum carriers by clearing chronic infections, but in its current form holds little promise for malaria elimination. Hopes that "highly sensitive" diagnostic tests would provide substantial advances in screen and treat programmes have been shown to be misplaced. To reduce the burden on P. falciparum and Plasmodium vivax infections in people working in forested areas novel approaches to the use of malaria prophylaxis in forest workers should be explored. During an October 2019 workshop in Phnom Penh researchers and policymakers reviewed evidence of acceptability, feasibility and effectiveness of interventions to target malaria foci and interrupt P. falciparum transmission and discussed operational requirements and conditions for programmatic implementation.
ISSN: 14752875
Appears in Collections:Scopus 2020

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