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Title: A rapid and simple method for routine determination of antibiotic sensitivity to biofilm populations of Pseudomonas aeruginosa
Authors: Dhammika Leshan Wannigama
Cameron Hurst
Parichart Hongsing
Lachlan Pearson
Thammakorn Saethang
Naphat Chantaravisoot
Uthaibhorn Singkham-In
Sirirat Luk-In
Robin James Storer
Tanittha Chatsuwan
University of Western Australia
Chulalongkorn University
QIMR Berghofer Medical Research Institute
Kasetsart University
Mae Fah Luang University
Mahidol University
The Westmead Institute for Medical Research
Keywords: Medicine
Issue Date: 13-Mar-2020
Citation: Annals of Clinical Microbiology and Antimicrobials. Vol.19, No.1 (2020)
Abstract: © 2020 The Author(s). Treatment of infections by Pseudomonas aeruginosa forming biofilms after antimicrobial testing on planktonic bacteria can result in substantial failure. Therefore, we offer a robust and simple experimental platform to test the impact of antimicrobials on biofilms. Antibiotic response patterns varied uniquely within biofilm formation capacity and minimal biofilm eradication concentrations (MBECs) has a significantly better discriminatory power than minimum inhibitory concentrations (MICs) to differentiate the overall efficiency of antibiotics to eradicate biofilm. Our resazurin-based 96-well-plate platform is able to emulate bacterial responses to antibiotics under biofilm conditions in a fast, simple, and cost-effective screening method adaptable to automation, and warrants trials in the clinic.
ISSN: 14760711
Appears in Collections:Scopus 2020

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