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Title: Human plasmodium vivax diversity, population structure and evolutionary origin
Authors: Virginie Rougeron
Eric Elguero
Céline Arnathau
Beatriz Acuña Hidalgo
Patrick Durand
Sandrine Houze
Antoine Berry
Sedigheh Zakeri
Rashidul Haque
Mohammad Shafiul Alam
François Nosten
Carlo Severini
Tamirat Gebru Woldearegai
Benjamin Mordmüller
Peter Gottfried Kremsner
Lilia González-Cerón
Gustavo Fontecha
Dionicia Gamboa
Lise Musset
Eric Legrand
Oscar Noya
Tepanata Pumpaibool
Pingchai Harnyuttanakorn
Khadijetou Mint Lekweiry
Musab Mohamad Albsheer
Muzamil Mahdi Abdel Hamid
Ali Ould Mohamed Salem Boukary
Jean François Trape
François Renaud
Franck Prugnolle
University of Nouakchott (Université de Nouakchott)
Universidad Peruana Cayetano Heredia, Instituto de Medicina Tropical Alexander von Humboldt
Maladies Infectieuses et Vecteurs : Écologie, Génétique, Évolution et Contrôle
Aix Marseille Université
Universidad Nacional Autónoma de Honduras
Institut Pasteur de la Guyane
Khartoum University
Haramaya University
Chulalongkorn University
Universite Paul Sabatier Toulouse III
CHU de Toulouse
Hôpital Bichat-Claude-Bernard AP-HP
Instituto Nacional de Salud Pública. México
Universität Tübingen
Mahidol University
International Centre for Diarrhoeal Disease Research Bangladesh
Istituto Superiore Di Sanita
Pasteur Institute of Iran
Institut Pasteur, Paris
Universidad Central de Venezuela
German Center for Infection Research (DZIF)
Centre for Tropical Medicine
Keywords: Medicine
Issue Date: 1-Jan-2020
Citation: PLoS Neglected Tropical Diseases. Vol.14, No.3 (2020), 1-17
Abstract: © 2020 Rougeron et al. More than 200 million malaria clinical cases are reported each year due to Plasmodium vivax, the most widespread Plasmodium species in the world. This species has been neglected and understudied for a long time, due to its lower mortality in comparison with Plasmodium falciparum. A renewed interest has emerged in the past decade with the dis-covery of antimalarial drug resistance and of severe and even fatal human cases. Nonethe-less, today there are still significant gaps in our understanding of the population genetics and evolutionary history of P. vivax, particularly because of a lack of genetic data from Africa. To address these gaps, we genotyped 14 microsatellite loci in 834 samples obtained from 28 locations in 20 countries from around the world. We discuss the worldwide population genetic structure and diversity and the evolutionary origin of P. vivax in the world and its introduction into the Americas. This study demonstrates the importance of conducting genome-wide analyses of P. vivax in order to unravel its complex evolutionary history.
ISSN: 19352735
Appears in Collections:Scopus 2020

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