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Title: Grape cane extracts as multifunctional rejuvenating cosmetic ingredient: Evaluation of sirtuin activity, tyrosinase inhibition and bioavailability potential
Authors: Magdalena Anna Malinowska
Kévin Billet
Samantha Drouet
Thibaut Munsch
Marianne Unlubayir
Duangjai Tungmunnithum
Nathalie Giglioli-Guivarc'H
Christophe Hano
Arnaud Lanoue
Biomolécules et Biotechnologies Végétales (BBV)
Universite d'Orleans
Politechnika Krakowska
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-May-2020
Citation: Molecules. Vol.25, No.9 (2020)
Abstract: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Grape canes are waste biomass of viticulture containing bioactive polyphenols valuable in cosmetics. Whereas several studies reported the cosmetic activities of E-resveratrol, only few described the potential of E-ϵ-viniferin, the second major constituent of grape cane extracts (GCE), and none of them investigated GCE as a natural blend of polyphenols for cosmetic applications. In this study, we considered the potential of GCE from polyphenol-rich grape varieties as multifunctional cosmetic ingredients. HPLC analysis was performed to quantify major polyphenols in GCE i.e., catechin, epicatechin, E-resveratrol, E-piceatannol, ampelopsin A, E-ϵ-viniferin, hopeaphenol, isohopeaphenol, E-miyabenol C and E-vitisin B from selected cultivars. Skin whitening potential through tyrosinase inhibition assay and the activation capacity of cell longevity protein (SIRT1) of GCE were compared to pure E-resveratrol and E-ϵ-viniferin. Drug-likeness of GCE polyphenols were calculated, allowing the prediction of skin permeability and bioavailability. Finally, the present data enabled the consideration of GCE frompolyphenol-rich varieties asmultifunctional cosmetic ingredients in accordance with green chemistry practices.
ISSN: 14203049
Appears in Collections:Scopus 2020

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