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Title: Expression of androgen receptor and its regulatory molecule lin28 in non-luminal subtype breast cancer
Authors: Doonyapat Sa-Nguanraksa
Wanee Pongthong
Norasate Samarnthai
Kwanlada Mitpakdi
Tuenjai Chuangsuwanich
Thawornchai Limjindaporn
Anchalee Kulprom
Pornchai O-Charoenrat
Faculty of Medicine, Siriraj Hospital, Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology;Medicine
Issue Date: 1-Jan-2020
Citation: Molecular and Clinical Oncology. Vol.12, No.6 (2020), 511-518
Abstract: © 2020, Spandidos Publications. All rights reserved. Androgen receptor (AR) was associated with favourable outcome in luminal breast cancer. However, the role of AR in non-luminal breast cancer remains inconclusive. The aim of the present study was to evaluate the clinical significance of t he AR and its regulator y pat hway in non-luminal subtypes of breast cancer. In total, 284 breast cancer patients were recruited from January 2007 to January 2016. Tissue microarrays were constructed from archival paraffin blocks and assessed for AR and its regulatory molecule, Lin28, by immunohistochemistry. The association between AR and Lin28 expression and clinicopathological parameters was analyzed. Results showed that AR and Lin28 were co-expressed. No association between these proteins and clinicopathological parameters, and survival outcome was found. However, a higher proportion of the patients with AR and Lin28 expression were observed in HER2 subtype. In conclusion, Lin28 may be a novel marker for prognosis and targeted for treatment in HER2 subtype breast cancer.
ISSN: 20499469
Appears in Collections:Scopus 2020

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