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Title: Butein, isoliquiritigenin, and scopoletin attenuate neurodegenerationviaantioxidant enzymes and SIRT1/ADAM10 signaling pathway
Authors: Naw Hser Gay
Wilasinee Suwanjang
Waralee Ruankham
Napat Songtawee
Prapimpun Wongchitrat
Virapong Prachayasittikul
Supaluk Prachayasittikul
Kamonrat Phopin
Mahidol University
University of Medical Technology
Keywords: Chemical Engineering;Chemistry
Issue Date: 27-Apr-2020
Citation: RSC Advances. Vol.10, No.28 (2020), 16593-16606
Abstract: © The Royal Society of Chemistry 2020. Neuronal cell death is a key feature of neurodegenerative disorders such as Parkinson's and Alzheimer's diseases. Plant polyphenols, namely butein, isoliquiritigenin, and scopoletin, have been shown to exhibit various biological activities including anti-inflammatory, antimicrobial, and antioxidant activities. Herein, butein, isoliquiritigenin, and scopoletin were explored for their neuroprotective properties against oxidative stress-induced human dopaminergic SH-SY5Y cell death. The cells exposed to hydrogen peroxide (H2O2) revealed a reduction in cell viability and increases in apoptosis and levels of reactive oxygen species (ROS). Interestingly, pretreatment of SH-SY5Y cells with 5 µM of butein, isoliquiritigenin, or scopoletin protected against the cell death induced by H2O2, and decreased the levels of apoptotic cells and ROS. In addition, the levels of SIRT1, FoxO3a, ADAM10, BCL-2, and antioxidant enzymes (catalase and SOD2) were maintained in the cells pretreated with butein, isoliquiritigenin, or scopoletin before H2O2treatment compared to cells without pretreatment and the reference (resveratrol). Molecular docking analysis revealed that the interactions between the activator-binding sites of SIRT1 and the phenolic compounds were similar to those of resveratrol. Taken together, the data suggest that these polyphenolic compounds could be potential candidates for prevention and/or treatment of neurodegeneration.
ISSN: 20462069
Appears in Collections:Scopus 2020

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