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dc.contributor.authorKanhatai Chiengthongen_US
dc.contributor.authorWisit Cheungpasitpornen_US
dc.contributor.authorCharat Thongprayoonen_US
dc.contributor.authorPloypin Lertjitbanjongen_US
dc.contributor.authorLiam D. Catoen_US
dc.contributor.authorTarun Bathinien_US
dc.contributor.authorPatompong Ungpraserten_US
dc.contributor.authorMichael A. Maoen_US
dc.contributor.authorRonpichai Chokesuwattanaskulen_US
dc.contributor.otherUniversity Hospital Birmingham NHS Foundation Trusten_US
dc.contributor.otherKing Chulalongkorn Memorial Hospital, Faculty of Medicine Chulalongkorn Universityen_US
dc.contributor.otherFaculty of Medicine, Siriraj Hospital, Mahidol Universityen_US
dc.contributor.otherThe University of Arizonaen_US
dc.contributor.otherMayo Clinicen_US
dc.contributor.otherUniversity of Mississippi Medical Centeren_US
dc.contributor.otherThe Mary Imogene Bassett Hospitalen_US
dc.contributor.otherMayo Clinic in Jacksonville, Floridaen_US
dc.identifier.citationJournal of Evidence-Based Medicine. (2020)en_US
dc.description.abstract© 2020 Chinese Cochrane Center, West China Hospital of Sichuan University and John Wiley & Sons Australia, Ltd Objective: Vitamin D status plays an important role in immunoregulation, and a deficiency is believed to be related to Graft Versus Host Disease (GVHD) in patients after hematopoietic stem cell transplantation (HSCT). We aim to study the association between vitamin D deficiency and GVHD after HSCT. Methods: A literature search was conducted utilizing MEDLINE, EMBASE, and The Cochrane Library Database from inception to July 2019. Eligible studies were required to1 be clinical trials or observational studies (cohort, case-control, or cross-sectional studies);2 provide data to calculate the odds ratios (OR) of GVHD in HSCT patients with vitamin D deficiency. Two reviewers independently extracted the data and assessed the risk of bias. Pooled odds ratios (OR) with 95% confidence interval (CI) were estimated using random-effects meta-analysis through the Comprehensive Meta-Analysis 3.3 software. Results: In total, 8 observational studies consisting of 1335 HSCT patients were enrolled in this systematic review. Overall, there was no significant association between vitamin D deficiency and acute GVHD (OR = 1.06, 95% CI 0.74-1.53, P > 0.05). There was no significant association between vitamin D deficiency and chronic GVHD (OR = 1.75, 95% CI 0.72-4.26, P > 0.05). Funnel plots and Egger regression asymmetry test were performed and showed no publication bias. Conclusion: There is not a statistically significant association between vitamin D deficiency and neither acute nor chronic GVHD.en_US
dc.rightsMahidol Universityen_US
dc.titleVitamin D deficiency is not associated with graft versus host disease after hematopoietic stem cell transplantation: A meta-analysisen_US
Appears in Collections:Scopus 2020

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