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dc.contributor.authorEkasit Sonphoen_US
dc.contributor.authorChanida Wootthichairangsanen_US
dc.contributor.authorMiyuki Ishidaen_US
dc.contributor.authorTakeshi Inoueen_US
dc.contributor.authorKiyokazu Agataen_US
dc.contributor.authorAnchuleerat Maleehuanen_US
dc.contributor.authorKomgrid Charngkaewen_US
dc.contributor.authorNusara Chomaneeen_US
dc.contributor.authorSaengduen Moonsomen_US
dc.contributor.authorPatompon Wongtrakoongateen_US
dc.contributor.authorArthit Chairoungduaen_US
dc.contributor.authorPuey Ounjaien_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherGakushuin Universityen_US
dc.contributor.otherMinistry of Educationen_US
dc.date.accessioned2020-08-25T08:48:27Z-
dc.date.available2020-08-25T08:48:27Z-
dc.date.issued2020-08-01en_US
dc.identifier.citationZoological science. Vol.37, No.4 (2020), 307-313en_US
dc.identifier.issn02890003en_US
dc.identifier.other2-s2.0-85089126782en_US
dc.identifier.urihttp://repository.li.mahidol.ac.th/dspace/handle/123456789/57588-
dc.description.abstractExtracellular matrix (ECM) plays key roles in shaping fates of stem cells, not only by providing a suitable niche but also by mediating physical and biochemical cues. Despite intensive investigations on regeneration, the roles of ECM in fate determination of stem cells in animals with great regenerative potency, such as planarian, have remained unclear. Here, we developed a method for decellularizing and isolating extracellular matrix from planarians. Although the isolated scaffold appears translucent, it contains all the internal features resembling those of the structure of intact planarians, and we thus called it the "ECM-body". Nuclear staining demonstrated that the ECM-body contains very few or no remaining cells. Histological sections displayed well-preserved morphological integrity of the specimen. Scanning electron microscopy showed a porous surface on the ECM-body, potentially suitable for housing cells. Furthermore, our preliminary experiment suggested that ECM-body can be utilized as a biomimetic scaffold for cell culture as it may support survival of injected neoblasts.en_US
dc.rightsMahidol Universityen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85089126782&origin=inwarden_US
dc.subjectAgricultural and Biological Sciencesen_US
dc.titleECM-Body: A Cell-Free 3D Biomimetic Scaffold Derived from Intact Planarian Bodyen_US
dc.typeArticleen_US
dc.rights.holderSCOPUSen_US
dc.identifier.doi10.2108/zs190135en_US
dc.identifier.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85089126782&origin=inwarden_US
Appears in Collections:Scopus 2020

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