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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/57668
Title: Plasma-derived extracellular vesicles from Plasmodium vivax patients signal spleen fibroblasts via NF-kB facilitating parasite cytoadherence
Authors: Haruka Toda
Miriam Diaz-Varela
Joan Segui-Barber
Wanlapa Roobsoong
Barbara Baro
Susana Garcia-Silva
Alicia Galiano
Melisa Gualdrón-López
Anne C.G. Almeida
Marcelo A.M. Brito
Gisely Cardoso de Melo
Iris Aparici-Herraiz
Carlos Castro-Cavadía
Wuelton Marcelo Monteiro
Eva Borràs
Eduard Sabidó
Igor C. Almeida
Jakub Chojnacki
Javier Martinez-Picado
Maria Calvo
Pilar Armengol
Jaime Carmona-Fonseca
Maria Fernanda Yasnot
Ricardo Lauzurica
Antonio Marcilla
Hector Peinado
Mary R. Galinski
Marcus V.G. Lacerda
Jetsumon Sattabongkot
Carmen Fernandez-Becerra
Hernando A. del Portillo
Universidad de Córdoba, Monteria
Barcelona Institute of Science and Technology (BIST)
Instituto de Salud Global de Barcelona
Fundacao de Medicina Tropical do Amazonas
Universitat de Vic - Universitat Central de Catalunya (UVic-UCC)
Universidad de Antioquia
Universitat Pompeu Fabra Barcelona
Institució Catalana de Recerca i Estudis Avançats
Hospital Universitari Germans Trias i Pujol
Fundacao Oswaldo Cruz
Mahidol University
Centro Nacional de Investigaciones Oncológicas
The University of Texas at El Paso
University of Valencia
Universidade do Estado do Amazonas
Universitat de Barcelona
Fundació Institut dInvestigació en Ciències de la Salut Germans Trias i Pujol
Emory University
IrsiCaixa AIDS Research Institute
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry;Physics and Astronomy
Issue Date: 1-Dec-2020
Citation: Nature Communications. Vol.11, No.1 (2020)
Abstract: © 2020, The Author(s). Plasmodium vivax is the most widely distributed human malaria parasite. Previous studies have shown that circulating microparticles during P. vivax acute attacks are indirectly associated with severity. Extracellular vesicles (EVs) are therefore major components of circulating plasma holding insights into pathological processes. Here, we demonstrate that plasma-derived EVs from Plasmodium vivax patients (PvEVs) are preferentially uptaken by human spleen fibroblasts (hSFs) as compared to the uptake of EVs from healthy individuals. Moreover, this uptake induces specific upregulation of ICAM-1 associated with the translocation of NF-kB to the nucleus. After this uptake, P. vivax-infected reticulocytes obtained from patients show specific adhesion properties to hSFs, reversed by inhibiting NF-kB translocation to the nucleus. Together, these data provide physiological EV-based insights into the mechanisms of human malaria pathology and support the existence of P. vivax-adherent parasite subpopulations in the microvasculature of the human spleen.
URI: http://repository.li.mahidol.ac.th/dspace/handle/123456789/57668
metadata.dc.identifier.url: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85085909618&origin=inward
ISSN: 20411723
Appears in Collections:Scopus 2020

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