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Title: Generation of a serine/threonine-protein kinase LATS1 gene-edited iPSC MUSIi012-A-3
Authors: Chanchao Lorthongpanich
Chuti Laowtammathron
Nittaya Jiamvoraphong
Pimonwan Srisook
Pimjai Chingsuwanrote
Phatchanat Klaihmon
Supaporn Waeteekul
Yaowalak U-pratya
Surapol Issaragrisil
Faculty of Medicine, Siriraj Hospital, Mahidol University
Wattanosoth Hospital
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Oct-2020
Citation: Stem Cell Research. Vol.48, (2020)
Abstract: © 2020 The Authors In mammals, there are a number of kinases, including serine/threonine-protein kinase LATS1, that act as a core kinase of the Hippo pathway and that negatively regulate the Hippo effector protein YAP and its paralog TAZ. Using CRISPR/Cas9 technology, we established a stable LATS1 knockdown (LATS1-KD) iPSC from the MUSIi012-A cell line. The LATS1-KD iPSC MUSIi012-A-3 that was developed maintained both the normal karyotype and the pluripotent phenotype, and retained the ability to differentiate into all three embryonic germ layers.
ISSN: 18767753
Appears in Collections:Scopus 2020

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