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Title: E8002 inhibits peripheral nerve adhesion by enhancing fibrinolysis of l-ascorbic acid in a rat sciatic nerve model
Authors: Kiyoshi Kikuchi
Kentaro Setoyama
Seiya Takada
Shotaro Otsuka
Kazuki Nakanishi
Kosuke Norimatsu
Akira Tani
Harutoshi Sakakima
Ko Ichi Kawahara
Kazuya Hosokawa
Ryoji Kiyama
Megumi Sumizono
Salunya Tancharoen
Ikuro Maruyama
Gohsuke Hattori
Motohiro Morioka
Eiichiro Tanaka
Hisaaki Uchikado
Kagoshima University Graduate School of Medical and Dental Sciences
Kyushu University of Nursing and Social Welfare
Osaka Institute of Technology
Kagoshima University
Kagoshima University Faculty of Medicine
Mahidol University
Kurume University School of Medicine
Uchikado Neuro-Spine Clinic
Fujimori Kogyo Co., Ltd.
Keywords: Biochemistry, Genetics and Molecular Biology;Chemical Engineering;Chemistry;Computer Science
Issue Date: 1-Jun-2020
Citation: International Journal of Molecular Sciences. Vol.21, No.11 (2020)
Abstract: © 2020 by the authors. Perineural adhesions leading to neuropathy are one of the most undesirable consequences of peripheral nerve surgery. However, there are currently no widely used compounds with anti-adhesive effects in the field of peripheral nerve surgery. E8002 is a novel, anti-adhesive, multi-layer membrane that contains L-ascorbic acid (AA). Here, we investigated the effect and mechanism of E8002 in a rat sciatic nerve adhesion model. A total of 21 rats were used. Six weeks after surgery, macroscopic adhesion scores were significantly lower in the E8002 group (adhesion procedure followed by nerve wrapping with E8002) compared to the E8002 AA(−) group (adhesion procedure followed by nerve wrapping with the E8002 membrane excluding AA) and adhesion group (adhesion procedure but no treatment). Correspondingly, a microscopic examination revealed prominent scar tissue in the E8002 AA(−) and adhesion groups. Furthermore, an in vitro study using human blood samples showed that AA enhanced tissue-type, plasminogen activator-mediated fibrinolysis. Altogether, these results suggest that E8002 may exert an anti-adhesive action via AA and the regulation of fibrinolysis.
ISSN: 14220067
Appears in Collections:Scopus 2020

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