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Title: Event-free survival at 12 months is a strong surrogate endpoint for stage 1 diffuse large B cell lymphoma: a report from Nation Wide Registry Thai Lymphoma Study Group
Authors: Kitsada Wudhikarn
Udomsak Bunworasate
Jakrawadee Julamanee
Arnuparp Lekhakula
Supachai Ekwattanakit
Archrob Khuhapinant
Pimjai Niparuck
Suporn Chuncharunee
Tontanai Numbenjapon
Kannadit Prayongratana
Nonglak Kanitsap
Somchai Wongkhantee
Nisa Makruasi
Peerapon Wong
Lalita Norasetthada
Weerasak Nawarawong
Chittima Sirijerachai
Kanchana Chansung
Tawatchai Suwanban
Pannee Praditsuktavorn
Tanin Intragumtornchai
Chulalongkorn University
Naresuan University
Khon Kaen University
Faculty of Medicine, Ramathibodi Hospital, Mahidol University
Thammasat University
Faculty of Medicine, Siriraj Hospital, Mahidol University
Phramongkutklao College of Medicine
Prince of Songkla University
Rajavithi Hospital
Chiang Mai University
Srinakharinwirot University
Khonkaen Regional Hospital
Chulabhorn Hospital
Keywords: Biochemistry, Genetics and Molecular Biology;Medicine
Issue Date: 1-Jan-2020
Citation: Leukemia and Lymphoma. (2020)
Abstract: © 2020, © 2020 Informa UK Limited, trading as Taylor & Francis Group. Event-free survival at 12 months (EFS12) is a surrogate endpoint for long-term outcomes in many histologic lymphoma subtypes. However, most reports have primarily investigated the implication of EFS12 in advanced-stage non-Hodgkin lymphoma (NHL). There are limited data regarding the significance of EFS12 in early-stage NHL. Herein, we evaluated the prognostic significance of EFS12 in patients with stage 1 diffuse large B-cell lymphoma (DLBCL). Out of 282 patients with stage 1 DLBCL who received intensive therapy, 227 (80.5%) achieved EFS12. The 4-year overall survival (OS) was 91.4% and 4.0% for patients who achieved and failed to achieve EFS12, respectively. Multivariable analyses demonstrated response to treatment and achievement of EFS12 as independent predictors for OS. In conclusion, our study demonstrated EFS12 as a powerful prognostic factor for stage 1 DLBCL. Further validation in more extensive prospective studies is warranted.
ISSN: 10292403
Appears in Collections:Scopus 2020

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