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Title: Implementing parasite genotyping into national surveillance frameworks: feedback from control programmes and researchers in the Asia-Pacific region
Authors: Rintis Noviyanti
Olivo Miotto
Alyssa Barry
Jutta Marfurt
Sasha Siegel
Nguyen Thuy-Nhien
Huynh Hong Quang
Nancy Dian Anggraeni
Ferdinand Laihad
Yaobao Liu
Maria Endang Sumiwi
Hidayat Trimarsanto
Farah Coutrier
Nadia Fadila
Najia Ghanchi
Fatema Tuj Johora
Agatha Mia Puspitasari
Livingstone Tavul
Leily Trianty
Retno Ayu Setya Utami
Duoquan Wang
Kesang Wangchuck
Ric N. Price
Sarah Auburn
Oxford University Clinical Research Unit
Jiangsu Institute of Parasitic Diseases
Papua New Guinea Institute of Medical Research
Eijkman Institute for Molecular Biology
Ministry of Health, Republic of Indonesia
The Aga Khan University Hospital
Chinese Center for Disease Control and Prevention
Walter and Eliza Hall Institute of Medical Research
University of Melbourne
Menzies School of Health Research
Deakin University
Mahidol University
International Centre for Diarrhoeal Disease Research Bangladesh
Nuffield Department of Medicine
Burnet Institute
University of Oxford Medical Sciences Division
Ministry of Health
Institute of Malariology, Parasitology and Entomology
Keywords: Immunology and Microbiology;Medicine
Issue Date: 27-Jul-2020
Citation: Malaria journal. Vol.19, No.1 (2020), 271
Abstract: The Asia-Pacific region faces formidable challenges in achieving malaria elimination by the proposed target in 2030. Molecular surveillance of Plasmodium parasites can provide important information on malaria transmission and adaptation, which can inform national malaria control programmes (NMCPs) in decision-making processes. In November 2019 a parasite genotyping workshop was held in Jakarta, Indonesia, to review molecular approaches for parasite surveillance and explore ways in which these tools can be integrated into public health systems and inform policy. The meeting was attended by 70 participants from 8 malaria-endemic countries and partners of the Asia Pacific Malaria Elimination Network. The participants acknowledged the utility of multiple use cases for parasite genotyping including: quantifying the prevalence of drug resistant parasites, predicting risks of treatment failure, identifying major routes and reservoirs of infection, monitoring imported malaria and its contribution to local transmission, characterizing the origins and dynamics of malaria outbreaks, and estimating the frequency of Plasmodium vivax relapses. However, the priority of each use case varies with different endemic settings. Although a one-size-fits-all approach to molecular surveillance is unlikely to be applicable across the Asia-Pacific region, consensus on the spectrum of added-value activities will help support data sharing across national boundaries. Knowledge exchange is needed to establish local expertise in different laboratory-based methodologies and bioinformatics processes. Collaborative research involving local and international teams will help maximize the impact of analytical outputs on the operational needs of NMCPs. Research is also needed to explore the cost-effectiveness of genetic epidemiology for different use cases to help to leverage funding for wide-scale implementation. Engagement between NMCPs and local researchers will be critical throughout this process.
ISSN: 14752875
Appears in Collections:Scopus 2020

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