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Title: Immunogenicity and efficacy of zika virus envelope domain III in DNA, protein, and ChAdOx1 adenoviral-vectored vaccines
Authors: César López-Camacho
Giuditta De Lorenzo
Jose Luis Slon-Campos
Stuart Dowall
Peter Abbink
Rafael A. Larocca
Young Chan Kim
Monica Poggianella
Victoria Graham
Stephen Findlay-Wilson
Emma Rayner
Jennifer Carmichael
Wanwisa Dejnirattisai
Michael Boyd
Roger Hewson
Juthathip Mongkolsapaya
Gavin R. Screaton
Dan H. Barouch
Oscar R. Burrone
Arvind H. Patel
Arturo Reyes-Sandoval
MRC-University of Glasgow Centre for Virus Research
Public Health England
International Centre for Genetic Engineering and Biotechnology
University of Oxford
Faculty of Medicine, Siriraj Hospital, Mahidol University
Nuffield Department of Medicine
Harvard Medical School
Keywords: Immunology and Microbiology;Medicine;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Jun-2020
Citation: Vaccines. Vol.8, No.2 (2020), 1-20
Abstract: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. The flavivirus envelope protein domain III (EDIII) was an effective immunogen against dengue virus (DENV) and other related flaviviruses. Whether this can be applied to the Zika virus (ZIKV) vaccinology remains an open question. Here, we tested the efficacy of ZIKV-EDIII against ZIKV infection, using several vaccine platforms that present the antigen in various ways. We provide data demonstrating that mice vaccinated with a ZIKV-EDIII as DNA or protein-based vaccines failed to raise fully neutralizing antibodies and did not control viremia, following a ZIKV challenge, despite eliciting robust antibody responses. Furthermore, we showed that ZIKV-EDIII encoded in replication-deficient Chimpanzee adenovirus (ChAdOx1-EDIII) elicited anti-ZIKV envelope antibodies in vaccinated mice but also provided limited protection against ZIKV in two physiologically different mouse challenge models. Taken together, our data indicate that contrary to what was shown for other flaviviruses like the dengue virus, which has close similarities with ZIKV-EDIII, this antigen might not be a suitable vaccine candidate for the correct induction of protective immune responses against ZIKV.
ISSN: 2076393X
Appears in Collections:Scopus 2020

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