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Title: Call to Action: SARS-CoV-2 and CerebrovAscular DisordErs (CASCADE)
Authors: Shahram Abootalebi
Benjamin M. Aertker
Mohammad Sobhan Andalibi
Negar Asdaghi
Ozlem Aykac
M. Reza Azarpazhooh
M. Cecilia Bahit
Kristian Barlinn
Hamidon Basri
Reza Bavarsad Shahripour
Anna Bersano
Jose Biller
Afshin Borhani-Haghighi
Robert D. Brown
Bruce CV Campbell
Salvador Cruz-Flores
Deidre Anne De Silva
Mario Di Napoli
Afshin A. Divani
Randall C. Edgell
Johanna T. Fifi
Abdoreza Ghoreishi
Teruyuki Hirano
Keun Sik Hong
Chung Y. Hsu
Josephine F. Huang
Manabu Inoue
Amanda L. Jagolino
Moira Kapral
Hoo Fan Kee
Zafer Keser
Rakesh Khatri
Masatoshi Koga
Jerzy Krupinski
David S. Liebeskind
Liping Liu
Henry Ma
Alberto Maud
Louise D. McCullough
Dawn Matherne Meyer
Victoria Mifsud
Negar Morovatdar
Yongchai Nilanont
Thomas J. Oxley
Atilla Özcan Özdemir
Jeyaraj Pandian
Leonardo Pantoni
Nikolaos I.H. Papamitsakis
Adrian Parry-Jones
Thanh Phan
Gustavo Rodriguez
Jose G. Romano
Ziad Sabaa-Ayoun
Hamidreza Saber
Payam Sasannezhad
Jeffrey L. Saver
Eugene Scharf
Ashfaq Shuaib
Brian Silver
Shaloo Singhal
Craig J. Smith
Saverio Stranges
P. N. Sylaja
Michel Torbey
Kazunori Toyoda
Georgios Tsivgoulis
Mohammad Wasay
Nawaf Yassi
Takeshi Yoshimoto
Babak Zamani
Ramin Zand
Clinical Neurology Research Center
Beijing Tiantan Hospital, Capital Medical University
Luxembourg Institute of Health
The Aga Khan University
UNM School of Medicine
University of Alberta
University of California, San Diego
Robarts Research Institute
University of Miami
Eskişehir Osmangazi Üniversitesi
St. Louis University
Sree Chitra Tirunal Institute for Medical Sciences and Technology
University of Melbourne
Dresden University Faculty of Medicine and University Hospital Carl Gustav Carus
Universiti Putra Malaysia
Iran University of Medical Sciences
SUNY Downstate Health Sciences University
Manchester Metropolitan University
Cleveland Clinic Foundation
Kyorin University
Monash University
Singapore General Hospital
Institute for Clinical Evaluative Sciences
Foundation IRCCS Neurological Institute "C. Besta"
University of Toronto
Loyola University Health System
Kokuritsu Junkankibyo Senta
Dalhousie University
Attikon University Hospital
Inje University
Icahn School of Medicine at Mount Sinai
University of Zanjan
Faculty of Medicine, Siriraj Hospital, Mahidol University
Western University
Salford Royal NHS FoundationTrust
Geisinger Health System
China Medical University Taichung
Christian Medical College & Hospital, Ludhiana
Mayo Clinic
David Geffen School of Medicine at UCLA
The Mount Sinai Hospital
The University of Manchester
Mayo Clinic in Jacksonville, Florida
Ospedale Luigi Sacco - Polo Universitario
University of Tennessee Health Science Center
Mashhad University of Medical Sciences
University of Massachusetts Medical School
Chief of Cardiology
UTHealth McGovern Medical School
SMDN-Centre for Cardiovascular Medicine and Cerebrovascular Disease Prevention
Texas Tech Health University Health Sciences Center
Hospital Universitari Mútua Terrassa
San Camillo de' Lellis District General Hospital
Keywords: Medicine
Issue Date: 1-Sep-2020
Citation: Journal of Stroke and Cerebrovascular Diseases. Vol.29, No.9 (2020)
Abstract: © 2020 Background and purpose: The novel severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2), now named coronavirus disease 2019 (COVID-19), may change the risk of stroke through an enhanced systemic inflammatory response, hypercoagulable state, and endothelial damage in the cerebrovascular system. Moreover, due to the current pandemic, some countries have prioritized health resources towards COVID-19 management, making it more challenging to appropriately care for other potentially disabling and fatal diseases such as stroke. The aim of this study is to identify and describe changes in stroke epidemiological trends before, during, and after the COVID-19 pandemic. Methods: This is an international, multicenter, hospital-based study on stroke incidence and outcomes during the COVID-19 pandemic. We will describe patterns in stroke management, stroke hospitalization rate, and stroke severity, subtype (ischemic/hemorrhagic), and outcomes (including in-hospital mortality) in 2020 during COVID-19 pandemic, comparing them with the corresponding data from 2018 and 2019, and subsequently 2021. We will also use an interrupted time series (ITS) analysis to assess the change in stroke hospitalization rates before, during, and after COVID-19, in each participating center. Conclusion: The proposed study will potentially enable us to better understand the changes in stroke care protocols, differential hospitalization rate, and severity of stroke, as it pertains to the COVID-19 pandemic. Ultimately, this will help guide clinical-based policies surrounding COVID-19 and other similar global pandemics to ensure that management of cerebrovascular comorbidity is appropriately prioritized during the global crisis. It will also guide public health guidelines for at-risk populations to reduce risks of complications from such comorbidities.
ISSN: 15328511
Appears in Collections:Scopus 2020

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